Gain control by layer six in cortical circuits of vision.
Gain control by layer six in cortical circuits of vision.
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DOI：
10.1038/nature10835
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发表时间：
2012-02-22
期刊：
影响因子：
64.8
通讯作者：
Scanziani, Massimo
中科院分区：
文献类型：
--
作者：
Olsen, Shawn R.;Bortone, Dante S.;Adesnik, Hillel;Scanziani, Massimo
在进入大脑皮层后，感觉信息通过六个不同的水平神经元层传播，这些神经元层通过垂直轴突投射相互连接。据信，通过这些投射层可以影响彼此对感官刺激的反应，但每个层在皮层处理中所扮演的特定角色仍然知之甚少。在这里，我们表明，第6层在小鼠的初级视觉皮层中起着至关重要的作用，在控制增益的视觉诱发活动的神经元的上层，但没有改变他们的调谐方向。这种增益调制是由第6层投射到浅层和深层投射到丘脑的协调作用引起的，前一个回路发挥了重要作用。因此，这项研究确立了L6作为皮层增益调制的主要介质，并建议它可能是一个节点，通过它来自几个大脑区域的会聚输入可以调节皮层视觉处理的最早步骤。
Upon entering the cerebral cortex sensory information spreads through six different horizontal neuronal layers that are interconnected by vertical axonal projections. It is believed that through these projections layers can influence each other’s response to sensory stimuli, yet the specific role played by each layer in cortical processing is still poorly understood. Here we show that layer 6 in the primary visual cortex of the mouse plays a crucial role in controlling the gain of visually evoked activity in neurons of the upper layers without, however, changing their tuning to orientation. This gain modulation results from the coordinated action of layer 6 projections to superficial layers and deep projections to the thalamus, with a substantial role of the former circuit. This study thus establishes L6 as a major mediator of cortical gain modulation and suggests it could be a node through which convergent inputs from several brain areas can regulate the earliest steps of cortical visual processing.
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