Urocortin-3 neurons in the perifornical area are critical mediators of chronic stress on female infant-directed behavior.
Urocortin-3 neurons in the perifornical area are critical mediators of chronic stress on female infant-directed behavior.
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DOI：
10.1038/s41380-022-01902-2
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发表时间：
2023-01
影响因子：
11
通讯作者：
Autry, Anita E.
中科院分区：
文献类型：
--
作者：
Abdelmesih, Brenda;Anderson, Robyn;Bambah-Mukku, Dhananjay;Carta, Ilaria;Autry, Anita E.
在雄性和雌性小鼠中，下丘脑皮层周围区表达尿皮质素-3的神经元（PeFAUcn3）的激活促进了婴儿的逃避和攻击。PeFAUcn3神经元与压力有关，而压力会减少母性行为。我们询问慢性约束应激（CRS）如何影响处女和哺乳期雌性的婴儿导向行为，以及PeFAUcn3神经元在这一过程中起什么作用。在这里，我们发现婴儿导向行为增加了处子期和哺乳期雌性PeFAUcn3神经元的活性。化学发生抑制PeFAUcn3神经元有助于处女雌性幼崽的恢复。CRS减少了未交配雌性的幼仔回收，增加了PeFAUcn3神经元的活性，而CRS对哺乳期雌性的母性行为没有影响。抑制PeFAUcn3神经元可阻断应激诱导的雌性幼崽定向行为缺陷。总之，这些数据说明了PeFAUcn3神经元活动在介导慢性应激对女性婴儿导向行为的影响中的关键作用。
Infant avoidance and aggression are promoted by activation of the Urocortin-3 expressing neurons of the perifornical area of hypothalamus (PeFAUcn3) in male and female mice. PeFAUcn3 neurons have been implicated in stress, and stress is known to reduce maternal behavior. We asked how chronic restraint stress (CRS) affects infant-directed behavior in virgin and lactating females and what role PeFAUcn3 neurons play in this process. Here we show that infant-directed behavior increases activity in the PeFAUcn3 neurons in virgin and lactating females. Chemogenetic inhibition of PeFAUcn3 neurons facilitates pup retrieval in virgin females. CRS reduces pup retrieval in virgin females and increases activity of PeFAUcn3 neurons, while CRS does not affect maternal behavior in lactating females. Inhibition of PeFAUcn3 neurons blocks stress-induced deficits in pup-directed behavior in virgin females. Together, these data illustrate the critical role for PeFAUcn3 neuronal activity in mediating the impact of chronic stress on female infant-directed behavior.
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影响因子：
10.6
作者：
Autry, Anita E.;Adachi, Megumi;Cheng, Pengfei;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
64.8
作者：
Carcea I;Caraballo NL;Marlin BJ;Ooyama R;Riceberg JS;Mendoza Navarro JM;Opendak M;Diaz VE;Schuster L;Alvarado Torres MI;Lethin H;Ramos D;Minder J;Mendoza SL;Bair-Marshall CJ;Samadjopoulos GH;Hidema S;Falkner A;Lin D;Mar A;Wadghiri YZ;Nishimori K;Kikusui T;Mogi K;Sullivan RM;Froemke RC
通讯作者：
Froemke RC
影响因子：
5.3
作者：
Deussing, Jan M.;Breu, Johannes;Wurst, Wolfgang
通讯作者：
Wurst, Wolfgang
DOI：
10.1152/ajpregu.1998.275.5.r1438
发表时间：
1998-11-01
影响因子：
2.8
作者：
Bonaz, B;Rivest, S
通讯作者：
Rivest, S
影响因子：
16.2
作者：
Bielsky, IF;Hu, SB;Young, LJ
通讯作者：
Young, LJ