Sex differences in the pathways to major depression: a study of opposite-sex twin pairs.
Sex differences in the pathways to major depression: a study of opposite-sex twin pairs.
复制标题
DOI：
10.1176/appi.ajp.2013.13101375
复制
发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Gardner CO
中科院分区：
文献类型：
--
作者：
Kendler KS;Gardner CO
作者试图阐明重性抑郁症病因学途径中性别差异的本质。回顾性和前瞻性评估的20个发展组织的风险因素和发生的过去一年的抑郁症进行了两波个人访谈至少12个月，在1,057对异性双卵双胞胎对从人口为基础的登记。通过结构建模进行分析，检查配对内差异。在最佳拟合模型中，60%的路径表现出性别差异。在20个风险因素中，有11个在对重性抑郁症的影响上存在性别差异。其中五个因素对女性的影响更大：父母的温暖、神经质、离婚、社会支持和婚姻满意度。六个对男性有更大的影响：儿童期性虐待，行为障碍，药物滥用，既往重度抑郁症史，以及远端和依赖性近端压力生活事件。对男性影响更大的生活事件类别是经济、职业和法律的性质。在一个双胞胎对照设计中，在遗传和家庭环境背景上匹配兄弟姐妹篇，个性和人际关系失败在女性抑郁症中比男性起着更强的病因作用。外化的精神病理学，先前的抑郁症，和特定的“工具”类急性应激源更重要的病因途径，以男性抑郁症。结果与先前提出的重性抑郁症类型学一致，该类型学表明两种亚型在女性（关怀关系和人际关系缺失的缺陷）和男性（未能实现预期目标，自我价值降低）中的患病率不同。
The authors sought to clarify the nature of sex differences in the etiologic pathways to major depression. Retrospective and prospective assessments of 20 developmentally organized risk factors and the occurrence of past-year major depression were conducted at two waves of personal interviews at least 12 months apart in 1,057 opposite-sex dizygotic twin pairs from a population-based register. Analyses were conducted by structural modeling, examining within-pair differences. Sixty percent of all paths in the best-fit model exhibited sex differences. Eleven of the 20 risk factors differed across sexes in their impact on liability to major depression. Five had a greater impact in women: parental warmth, neuroticism, divorce, social support, and marital satisfaction. Six had a greater impact in men: childhood sexual abuse, conduct disorder, drug abuse, prior history of major depression, and distal and dependent proximal stressful life events. The life event categories responsible for the stronger effect in males were financial, occupational, and legal in nature. In a co-twin control design, which matches sisters and brothers on genetic and familial-environmental background, personality and failures in interpersonal relationships played a stronger etiologic role in major depression for women than for men. Externalizing psychopathology, prior depression, and specific “instrumental” classes of acute stressors were more important in the etiologic pathway to major depression for men. The results are consistent with previously proposed typologies of major depression that suggest two subtypes that differ in prevalence in women (deficiencies in caring relationships and interpersonal loss) and men (failures to achieve expected goals, with lowered self-worth).
登录
查看更多内容
影响因子：
17.7
作者：
Kendler, KS;Myers, J;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
--
作者：
Kendler, Kenneth S.;Gatz, Margaret;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.
DOI：
10.1007/s00420-001-0299-8
发表时间：
2002-04-01
影响因子：
3
作者：
Bildt, C;Michélsen, H
通讯作者：
Michélsen, H
影响因子：
11.3
作者：
BRESLAU, N;SCHULTZ, L;PETERSON, E
通讯作者：
PETERSON, E
影响因子：
3
作者：
AKAIKE, H
通讯作者：
AKAIKE, H