Epidemiology of Sapovirus Infections in a Birth Cohort in Peru.
Epidemiology of Sapovirus Infections in a Birth Cohort in Peru.
复制标题
DOI：
10.1093/cid/cix1103
复制
发表时间：
2018-06-01
期刊：
影响因子：
--
通讯作者：
Sapovirus Working Group
中科院分区：
文献类型：
--
作者：
Sánchez GJ;Mayta H;Pajuelo MJ;Neira K;Xiaofang L;Cabrera L;Ballard SB;Crabtree JE;Kelleher D;Cama V;Bern C;Oshitani H;Gilman RH;Saito M;Sapovirus Working Group
这是第一个在发展中国家对萨帕病毒感染进行积极监测的出生队列研究。据报道，在生命的头2年里，腺病毒感染和相关腹泻的发病率很高。病毒再感染是常见的，但罕见的相同基因型。腺病毒是急性胃肠炎（AGE）的主要病毒病因之一，特别是在已实施轮状病毒疫苗接种的地区。然而，社区一级自然感染的特点和影响尚未得到很好的记录。从秘鲁社区出生队列研究中随机选择的100名儿童的粪便样本进行了分析。每个月从2岁以下的儿童（n = 1669）收集所有腹泻性粪便和1例非腹泻性粪便，进行沙病毒检测。病毒脱落持续时间是通过检测在病毒阳性样本之前和之后收集的额外每周样本（n = 440）来确定的。1岁和2岁儿童的腺病毒感染率分别为每100个月4.3例和11.1例。到2岁时，82%的儿童至少有1次腺病毒感染，64%的儿童至少有1次腺病毒相关腹泻发作。平均脱落期为18.5天。175例感染中有112例检测到来自4个基因组（GI、GII、GIV和GV）的14种基因型。在基因组中，GI在有症状感染中比在无症状感染中更常见（优势比为3.1；95%可信区间为1.3-7.4）。59名儿童连续感染病毒，但只有3名儿童重复感染相同的基因型。在出生后的头2年，经常在社区一级的AGE儿童中检测到Sapovirus。儿童中由多种基因型引起的系列皂荚病毒感染表明，每种感染都具有基因型特异性免疫，这需要在疫苗开发中加以考虑。
This was the first birth cohort study with active surveillance of sapovirus infection in a developing country. High incidences of sapovirus infection and associated diarrhea during the first 2 years of life were reported. Sapovirus reinfection is common but rare with the same genotype. Sapovirus is one of the primary viral causes of acute gastroenteritis (AGE), especially where rotavirus vaccination has been implemented. The characteristics and impact of natural infection at the community level, however, have not been well documented. Stool samples were analyzed from 100 children randomly selected from a community-based birth cohort study in Peru. All diarrheal and 1 nondiarrheal stools collected trimonthly from children up to age 2 years (n = 1669) were tested for sapovirus detection. Viral shedding duration was determined by testing additional weekly samples (n = 440) collected before and after a sapovirus-positive sample. The incidence of sapovirus infection in the first and second years of life was 4.3 and 11.1 per 100 child-months, respectively. By age 2 years, 82% of children had at least 1 sapovirus infection, and 64% had at least 1 sapovirus-associated diarrhea episode. The median shedding period was 18.5 days. In 112 of 175 infections, 14 genotypes from 4 genogroups (GI, GII, GIV, and GV) were determined. Among genogroups, GI were more frequently found in symptomatic infections than in asymptomatic infections (odds ratio, 3.1; 95% confidence interval, 1.3–7.4). Fifty-nine children had serial sapovirus infections, but only 3 had repeated infection of the same genotype. Sapovirus was frequently detected in children with AGE at the community level during the first 2 years of life. Serial sapovirus infections by multiple genotypes in a child suggest genotype-specific immunity from each infection, which needs to be taken into account for vaccine development.
登录
查看更多内容
DOI：
10.1097/inf.0000000000000427
发表时间：
2014-11
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Becker-Dreps S;Bucardo F;Vilchez S;Zambrana LE;Liu L;Weber DJ;Peña R;Barclay L;Vinjé J;Hudgens MG;Nordgren J;Svensson L;Morgan DR;Espinoza F;Paniagua M
通讯作者：
Paniagua M
影响因子：
11.8
作者：
Lee LE;Cebelinski EA;Fuller C;Keene WE;Smith K;Vinjé J;Besser JM
通讯作者：
Besser JM
影响因子：
2.7
作者：
Leblanc, Danielle;Inglis, G. Douglas;Houde, Alain
通讯作者：
Houde, Alain
影响因子：
2.7
作者：
Harada, Seiya;Oka, Tomoichiro;Katayama, Kazuhiko
通讯作者：
Katayama, Kazuhiko
DOI：
10.1093/bioinformatics/bts199
发表时间：
2012-06-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Kearse M;Moir R;Wilson A;Stones-Havas S;Cheung M;Sturrock S;Buxton S;Cooper A;Markowitz S;Duran C;Thierer T;Ashton B;Meintjes P;Drummond A
通讯作者：
Drummond A