The Effect of Naoxintong Capsule in the Treatment of Patients with Cerebral Infarction and Carotid Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Trials.
The Effect of Naoxintong Capsule in the Treatment of Patients with Cerebral Infarction and Carotid Atherosclerosis: A Systematic Review and Meta-Analysis of Randomized Trials.
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脑心通胶囊治疗脑梗死合并颈动脉粥样硬化患者的疗效：随机试验的系统回顾和荟萃分析
DOI：
10.1155/2018/5892306
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Xiao Y
中科院分区：
文献类型：
--
作者：
Liang Q;Cai Y;Chen R;Chen W;Chen L;Xiao Y
目的脑心通胶囊（NXT）已广泛应用于脑梗死和颈动脉粥样硬化的治疗。然而，NXT对脑梗死和颈动脉粥样硬化的作用是否有强有力的证据尚不确定。对脑心通治疗脑梗死和颈动脉粥样硬化的随机试验进行系统评价和荟萃分析。方法检索科克伦图书馆、EMBASE、Medline数据库、万方数据库、中国知网和维普数据库，时间截止至2018年1月，不受语言限制。根据科克伦标准进行研究选择、数据提取、质量评估和数据分析。结果11篇文献（N=1141）符合Meta分析的纳入标准。Meta分析结果显示，与单纯常规治疗相比，脑心通联合常规治疗能显著改善美国国立卫生研究院卒中量表（NIHSS）评分（MD=-3.92，95%CI：-4.31~-3.52，P <0.00001），斑块面积（MD=-0.16，95%CI：-0.20~-0.13，P <0.00001），颈动脉内膜中层厚度（IMT）（MD=-0.23，95%CI：-0.26~-0.20，P <0.00001），总胆固醇（TC）（MD=-0.16，95%CI：-0.79~-0.42，P <0.00001），甘油三酯（TG）（MD=-0.69，95%CI：-0.88~-0.51，P <0.00001）、高密度脂蛋白胆固醇（HDL-C）低密度脂蛋白胆固醇（LDL-C）（MD =-0.42，95%CI：-0.58~-0.25，P <0.00001）。研究中未报告不良事件。结论脑心通治疗脑梗死合并颈动脉粥样硬化是一种安全有效的治疗方法。但由于纳入试验的临床异质性高、样本量小，还需要进一步规范化准备、大规模、严格设计的试验。
Objective Naoxintong capsule (NXT) has been widely used to treat patients with cerebral infarction and carotid atherosclerosis. However, it is uncertain whether there is robust evidence on the effects of NXT for cerebral infarction and carotid atherosclerosis. A systematic review and meta-analysis of randomized trials were performed to assess the efficacy of NXT in the treatment of cerebral infarction and carotid atherosclerosis. Methods The Cochrane Library, EMBASE, the Medline database, the Wanfang database, the China National Knowledge Infrastructure, and the VIP database were searched up to January 2018 with no language restrictions. Study selection, data extraction, quality assessment, and data analyses were performed according to the Cochrane standards. Results Eleven studies (N=1141) in total satisfied the inclusion criteria for the meta-analysis. The results of meta-analysis showed that compared with the conventional therapy alone, NXT combined with conventional therapy could significantly improve national institutes of health stroke scale (NIHSS) score (MD= -3.92, 95%CI: -4.31~-3.52, P<0.00001), plaque area (MD= -0.16, 95%CI: -0.20~-0.13, P<0.00001), carotid intima-media thickness (IMT) (MD= -0.23, 95%CI: -0.26~-0.20, P<0.00001), total cholesterol (TC) (MD= -0.16, 95%CI: -0.79~-0.42, P<0.00001), triglyceride (TG) (MD= -0.69, 95%CI: -0.88~-0.51, P<0.00001), high-density lipoprotein cholesterol (HDL-C) (MD= 0.23, 95%CI: 0.15~0.31, P<0.00001), and low-density lipoprotein cholesterol (LDL-C) (MD= -0.42, 95%CI: -0.58~-0.25, P<0.00001). There were no reported adverse events in the studies. Conclusions NXT is an effective and safe therapy option for patients with cerebral infarction and carotid atherosclerosis. However, due to the high clinical heterogeneity and small sample size of the included trials, further standardized preparation, large-scale and rigorously designed trials are needed.
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