Dopaminergic regulation of circadian food anticipatory activity rhythms in the rat.
Dopaminergic regulation of circadian food anticipatory activity rhythms in the rat.
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DOI：
10.1371/journal.pone.0082381
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mistlberger RE
中科院分区：
文献类型：
--
作者：
Smit AN;Patton DF;Michalik M;Opiol H;Mistlberger RE
昼夜活动节律由下丘脑视交叉上核（SCN）中的主起搏器和位于其他地方的食物可消化昼夜振荡器（FEOs）共同控制。SCN介导与每日光暗周期的同步，而FEO产生与日常用餐时间同步的活动节律。产生食物预期节律的FEOs的位置以及携带这些FEOs的途径仍有待澄清。为了深入了解夹带途径，我们开发了一个协议，用于测量响应药理学探针的预期活动节律的相移。我们用这个协议来研究多巴胺信号在昼夜食物预期的时间中的作用。为了产生稳定的食物预期节律，大鼠在光照后6小时开始喂食3小时/天，或在恒定光照下至少3周。然后，大鼠单独接受D2激动剂喹吡罗（1 mg/kg IP），或在用多巴胺合成抑制剂α-甲基对酪氨酸（AMPT）预处理后接受。通过与媒介物注射相比，在熄灯前1小时（进餐前19小时）给予喹吡罗诱导下一餐前活动开始的相位延迟。延迟移位较大的大鼠预处理AMPT，和较小的quinpirole管理4小时后lights-on.A显着的转变，没有观察到响应D1激动剂SKF 81297。这些结果提供的证据表明，在D2受体的信号参与相位控制的FEOs负责的昼夜食物预期节律的大鼠。
Circadian activity rhythms are jointly controlled by a master pacemaker in the hypothalamic suprachiasmatic nuclei (SCN) and by food-entrainable circadian oscillators (FEOs) located elsewhere. The SCN mediates synchrony to daily light-dark cycles, whereas FEOs generate activity rhythms synchronized with regular daily mealtimes. The location of FEOs generating food anticipation rhythms, and the pathways that entrain these FEOs, remain to be clarified. To gain insight into entrainment pathways, we developed a protocol for measuring phase shifts of anticipatory activity rhythms in response to pharmacological probes. We used this protocol to examine a role for dopamine signaling in the timing of circadian food anticipation. To generate a stable food anticipation rhythm, rats were fed 3h/day beginning 6-h after lights-on or in constant light for at least 3 weeks. Rats then received the D2 agonist quinpirole (1 mg/kg IP) alone or after pretreatment with the dopamine synthesis inhibitor α-methylparatyrosine (AMPT). By comparison with vehicle injections, quinpirole administered 1-h before lights-off (19h before mealtime) induced a phase delay of activity onset prior to the next meal. Delay shifts were larger in rats pretreated with AMPT, and smaller following quinpirole administered 4-h after lights-on. A significant shift was not observed in response to the D1 agonist SKF81297. These results provide evidence that signaling at D2 receptors is involved in phase control of FEOs responsible for circadian food anticipatory rhythms in rats.
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影响因子：
2.7
作者：
Mendoza, J;Angeles-Castellanos, M;Escobar, C
通讯作者：
Escobar, C
DOI：
10.1007/bf01417860
发表时间：
1976-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
PITTENDRIGH, CS;DAAN, S
通讯作者：
DAAN, S
影响因子：
2.8
作者：
Jansen, Heiko T.;Sergeeva, Anna;Sorg, Barbara A.
通讯作者：
Sorg, Barbara A.
影响因子：
3.5
作者：
MISTLBERGER, RE
通讯作者：
MISTLBERGER, RE
影响因子：
3.7
作者：
Landry GJ;Opiol H;Marchant EG;Pavlovski I;Mear RJ;Hamson DK;Mistlberger RE
通讯作者：
Mistlberger RE