Scheduled daily mating induces circadian anticipatory activity rhythms in the male rat.
Scheduled daily mating induces circadian anticipatory activity rhythms in the male rat.
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DOI：
10.1371/journal.pone.0040895
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Mistlberger RE
中科院分区：
文献类型：
--
作者：
Landry GJ;Opiol H;Marchant EG;Pavlovski I;Mear RJ;Hamson DK;Mistlberger RE
每天有限地获取食物、美味的高热量零食、水和盐可以诱导大鼠和小鼠的预期运动活动的昼夜节律。所有这些刺激都是有益的，但预期是否可以由与食物和水合作用相关的代谢扰动无关的奖励相关神经诱导。研究人员进行了三项实验，以确定交配（一种非摄食行为，但却有潜在的回报）是否能诱导雄性大鼠的生理周期预期活动节律，这些雄性大鼠每天都有机会接触激素激发的发情雌性大鼠。在实验1中，大鼠期望在光照中期接近发情的雌性，但也表现出性交后进食和奔跑的行为。在实验2中，性交后进食和奔跑被阻止，只有少数大鼠表现出预期。被允许看到和闻到雌性发情的老鼠没有表现出预期。在这两项实验中，所有的大鼠都表现出持续的行为唤醒，在每次实验中都有多次坐床和射精，但每2-3天才射精一次。在实验3中，给大鼠更多的时间与雌性个体在一起，连续28天在深夜，然后在中午，连续28天。射精率增加，预期在夜间活动中增强，在白天活动中减弱。在连续3天无交配的黑暗环境中，预期节律持续存在。在预期夜间交配时，大鼠表现出对管状笼子的明显偏好，而不是管状笼子对有交配笼子垃圾的锁着的笼子的偏好。这种明显的地点偏好在预期中午交配时是不存在的，这可能反映了每日性奖励的节奏。研究结果表明，交配是一种奖励刺激，能够诱导雄性大鼠预期行为的昼夜节律，并揭示了射精的关键作用，一天中的调节作用，以及不受控制的食物摄入的潜在混淆作用。
Daily schedules of limited access to food, palatable high calorie snacks, water and salt can induce circadian rhythms of anticipatory locomotor activity in rats and mice. All of these stimuli are rewarding, but whether anticipation can be induced by neural correlates of reward independent of metabolic perturbations associated with manipulations of food and hydration is unclear. Three experiments were conducted to determine whether mating, a non-ingestive behavior that is potently rewarding, can induce circadian anticipatory activity rhythms in male rats provided scheduled daily access to steroid-primed estrous female rats. In Experiment 1, rats anticipated access to estrous females in the mid-light period, but also exhibited post-coital eating and running. In Experiment 2, post-coital eating and running were prevented and only a minority of rats exhibited anticipation. Rats allowed to see and smell estrous females showed no anticipation. In both experiments, all rats exhibited sustained behavioral arousal and multiple mounts and intromissions during every session, but ejaculated only every 2–3 days. In Experiment 3, the rats were given more time with individual females, late at night for 28 days, and then in the midday for 28 days. Ejaculation rates increased and anticipation was robust to night sessions and significant although weaker to day sessions. The anticipation rhythm persisted during 3 days of constant dark without mating. During anticipation of nocturnal mating, the rats exhibited a significant preference for a tube to the mating cage over a tube to a locked cage with mating cage litter. This apparent place preference was absent during anticipation of midday mating, which may reflect a daily rhythm of sexual reward. The results establish mating as a reward stimulus capable of inducing circadian rhythms of anticipatory behavior in the male rat, and reveal a critical role for ejaculation, a modulatory role for time of day, and a potential confound role for uncontrolled food intake.
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影响因子：
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作者：
ABE, H;RUSAK, B
通讯作者：
RUSAK, B
影响因子：
2.9
作者：
Carr, KD
通讯作者：
Carr, KD
影响因子：
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作者：
Davis, Brooke A.;Fitzgerald, Maureen E.;Coolen, Lique M.
通讯作者：
Coolen, Lique M.
为食物而工作将夜间小鼠活动转移到一天。
影响因子：
3.7
作者：
Hut RA;Pilorz V;Boerema AS;Strijkstra AM;Daan S
通讯作者：
Daan S
影响因子：
2.7
作者：
BOULOS, Z;ROSENWASSER, AM;TERMAN, M
通讯作者：
TERMAN, M