Three-dimensional anatomical structure formed by granule cell layer and pyramidal cell layer in human hippocampus
Three-dimensional anatomical structure formed by granule cell layer and pyramidal cell layer in human hippocampus
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人体海马颗粒细胞层和锥体细胞层形成的三维解剖结构
DOI：
10.1007/s12565-022-00673-8
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发表时间：
2022
影响因子：
1.2
通讯作者：
Honma Satoru
中科院分区：
文献类型：
--
作者：
Kominami Rieko;Sonomura Takahiro;Ito Tetsufumi;Shinohara Harumichi;Kishibe Miyuki;Uemura Mamoru;Honma Satoru
在人类的海马体中，锥体层由海马体的下部组成，它是分段组织的。每一节与齿状回的颗粒层一起显示出结构上的统一性。在人类，被称为金字塔丘(PHS)的椭圆形突起由厚厚的金字塔细胞层(PL)组成，存在于海马体的下部，并沿纵轴分段组织。齿状回的颗粒细胞层(GL)不是光滑的，而是波状的结构。然而，突起和波动之间的细胞结构关系还没有得到很好的研究。在这里，我们的目的是阐明人类海马区PL和GL的三维细胞构筑。为此，我们用苏木素和伊红染色的人海马区的连续切片进行了GL和PL的三维重建。GL呈管状，背部有开口，内侧呈波状，形成指状突起。在指状突起的底部，GL的突起向外侧延伸，较长的突起到达外侧缘，而较短的突起在GL的内侧1/3附近消失。因此，GL的外侧部分呈松散的波状。在PL的腹侧面上，椭圆形的PHS呈矢状排列，而在俯视面上，每个PH形成一个椭圆形的槽。每个结构单元由底部的PH槽形成，在中上部有较长的GL突起，而较短的GL突起位于GL的侧缘和较长的突起之间。一个像数字一样的过程延伸到一个洞穴中。结果表明，PH和GL的一个单位构成了海马体的纵向节段结构。
In the human hippocampus, the pyramidal layer consists of the inferior aspect of the hippocampus which is organized segmentally. Each segment, together with granule layer of the dentate gyrus, exhibits structural unity. In humans, ellipsoidal protrusions called pyramidal hillocks (PHs), which consist of a thick pyramidal cell layer (PL), are present in the inferior aspect of the hippocampus, and are segmentally organized along a longitudinal axis. It is also known that the granule cell layer (GL) of the dentate gyrus (DG) is not a smooth but undulated structure. However, the cytoarchitectural relationships between the protrusions and undulation have yet to be studied well. Here, we aimed to clarify the three-dimensional cytoarchitecture of the PL and GL of human hippocampus. For that purpose, the GL and PL were three-dimensionally reconstructed from serial sections of human hippocampus stained with hematoxylin and eosin. The GL was shaped as tubing with an opening in the dorsal part, and undulated especially in the medial part, forming digit-like processes. In the base of a digit-like process, protrusions of the GL extended laterally, with longer ones reaching the lateral edge, whereas shorter ones disappeared around the medial 1/3 of the GL. Consequently, the lateral part of the GL was undulated loosely. In the ventral view of the PL, the ellipsoidal PHs were sagittally aligned, whereas in the top view, each PH formed an ellipsoidal trough. Each structural unit was formed by a trough of the PH along the bottom, and had a longer GL protrusion in the upper-center, and shorter GL protrusions located between the longer protrusions and the lateral edge of the GL. A digit-like process extended into a dens. It is concluded that a unit of the PH and the GL comprises the longitudinal segmental formation of the hippocampus.
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DOI：
10.1176/ajp.152.7.973
发表时间：
1995-07
期刊：
The American journal of psychiatry
影响因子：
--
作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
通讯作者：
J. Bremner;P. Randall;T. Scott;R. Bronen;J. Seibyl;S. Southwick;R. Delaney;G. McCarthy;D. Cha
影响因子：
4.2
作者：
Wisse, Laura E. M.;Biessels, Geert Jan;Geerlings, Mirjam I.
通讯作者：
Geerlings, Mirjam I.
扫描电子显微镜（SEM）观察到的人类海马：齿状回由神经元片层阵列组成。
DOI：
--
发表时间：
2013
期刊：
Okajimas Folia Anatomica Japonica
影响因子：
--
作者：
R. Kominami;H. Shinohara;S. Yasutaka;M. Kishibe
通讯作者：
M. Kishibe
人类大脑图谱
DOI：
--
发表时间：
1956
期刊：
影响因子：
--
作者：
E. Ludwig;J. Klingler
通讯作者：
J. Klingler
影响因子：
--
作者：
Velakoulis, D;Wood, SJ;Pantelis, C
通讯作者：
Pantelis, C