Sirtuins and Insulin Resistance
Sirtuins and Insulin Resistance
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Sirtuins 和胰岛素抵抗
DOI：
10.3389/fendo.2018.00748
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发表时间：
2018-12
影响因子：
5.2
通讯作者：
陈厚早
中科院分区：
文献类型：
--
作者：
周爽;唐小强;陈厚早
哺乳动物Sirtuins（SIRT 1 -7）是一个进化上保守的NAD+依赖性脱酰基酶和单ADP核糖基转移酶家族。Sirtuins显示不同的亚细胞定位和功能，并参与细胞存活，衰老，代谢和基因组稳定性。在哺乳动物Sirtuins中，SIRT 1和SIRT 6已被彻底研究，并具有突出的代谢调节作用。此外，SIRT 1和SIRT 6与肥胖、胰岛素抵抗、2型糖尿病（T2 DM）、脂肪肝疾病和心血管疾病有关。然而，其他Sirtuins的作用尚未完全了解。最近的研究表明，这些Sirtuins在炎症、线粒体功能障碍和能量代谢中也起重要作用。胰岛素抵抗是肥胖和代谢综合征的重要病理特征，也是2型糖尿病的核心缺陷。越来越多的临床和实验动物证据表明，剩余的Sirtuins通过不同的生物学机制在调节胰岛素抵抗中的潜在作用。本文综述了Sirtuins在胰岛素抵抗相关生理过程中的作用，包括炎症、线粒体功能障碍、胰岛素信号通路、葡萄糖和脂质代谢等。此外，我们强调必须解决这一领域的重大差距。
The mammalian Sirtuins (SIRT1-7) are an evolutionarily conserved family of NAD+-dependent deacylase and mono-ADP-ribosyltransferase. Sirtuins display distinct subcellular localizations and functions and are involved in cell survival, senescence, metabolism and genome stability. Among the mammalian Sirtuins, SIRT1 and SIRT6 have been thoroughly investigated and have prominent metabolic regulatory roles. Moreover, SIRT1 and SIRT6 have been implicated in obesity, insulin resistance, type 2 diabetes mellitus (T2DM), fatty liver disease and cardiovascular diseases. However, the roles of other Sirtuins are not fully understood. Recent studies have shown that these Sirtuins also play important roles in inflammation, mitochondrial dysfunction, and energy metabolism. Insulin resistance is the critical pathological trait of obesity and metabolic syndrome as well as the core defect in T2DM. Accumulating clinical and experimental animal evidence suggests the potential roles of the remaining Sirtuins in the regulation of insulin resistance through diverse biological mechanisms. In this review, we summarize recent advances in the understanding of the functions of Sirtuins in various insulin resistance-associated physiological processes, including inflammation, mitochondrial dysfunction, the insulin signaling pathway, glucose, and lipid metabolism. In addition, we highlight the important gaps that must be addressed in this field.
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影响因子：
--
作者：
Maiese K
通讯作者：
Maiese K
NKG2D配体的表观遗传调控参与Sirt6杂合小鼠动脉粥样硬化的加剧
影响因子：
4.6
作者：
Zhang ZQ;Ren SC;Tan Y;Li ZZ;Tang X;Wang TT;Hao DL;Zhao X;Chen HZ;Liu DP
通讯作者：
Liu DP
影响因子：
120.1
作者：
Madeo, Frank;Pietrocola, Federico;Kroemer, Guido
通讯作者：
Kroemer, Guido
影响因子：
16
作者：
Hirschey MD;Shimazu T;Jing E;Grueter CA;Collins AM;Aouizerat B;Stančáková A;Goetzman E;Lam MM;Schwer B;Stevens RD;Muehlbauer MJ;Kakar S;Bass NM;Kuusisto J;Laakso M;Alt FW;Newgard CB;Farese RV Jr;Kahn CR;Verdin E
通讯作者：
Verdin E
影响因子：
1.6
作者：
Meehan CA;Cochran E;Mattingly M;Gorden P;Brown RJ
通讯作者：
Brown RJ