Body mass index and its association with COVID-19 clinical outcomes: Findings from the Philippine CORONA study.
Body mass index and its association with COVID-19 clinical outcomes: Findings from the Philippine CORONA study.
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DOI：
10.1016/j.clnesp.2022.03.013
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发表时间：
2022-06
影响因子：
3
通讯作者：
Jamora RDG
中科院分区：
文献类型：
--
作者：
Espiritu AI;Reyes NGD;Leochico CFD;Sy MCC;Villanueva Iii EQ;Anlacan VMM;Jamora RDG
在2019冠状病毒病（COVID-19）大型患者队列中探索体重指数（BMI）与不良结局之间的相关性。这是对一项37家临床试验机构、全国性、多中心、回顾性队列研究的二次分析，该研究调查了2020年2月至12月15日期间收治的确诊COVID-19成人患者的临床和神经系统结局。我们分析了4，463名患者的BMI和结局数据。分别有790例（17.7%）和710例（15.9%）患者的主要结局为院内死亡率和是否需要有创机械通气（IMV）。WHO BMI组与这些结果之间无显著相关性。使用亚太临界值显示肥胖与住院死亡风险之间存在显著相关性（P = 0.012）。无论采用何种BMI标准，体重不足都是延长IMV需求的独立预测因素（P < 0.01）。使用亚太地区临界值，肥胖与重症监护病房入院的需求相关（P = 0.029）。任何BMI异常与重度/危重COVID-19的几率之间存在显著相关性（P < 0.05）。在COVID-19住院期间伴随急性神经系统表现/诊断的肥胖患者显示神经系统恢复的几率较低（P < 0.05）。我们发现BMI异常与几种不良的临床和神经学结果相关，尽管这种相关性在使用种族特异性BMI标准时可能更明显。
To explore the association between body mass index (BMI) and adverse outcomes in a large cohort of patients with coronavirus disease 2019 (COVID-19). This is a secondary analysis of a 37-site, nationwide, multicenter, retrospective cohort study that investigated the clinical and neurological outcomes of adult patients with confirmed COVID-19 admitted from February to December 15, 2020. We analyzed 4,463 patients with BMI and outcome data. A total of 790 (17.7%) and 710 (15.9%) had the primary outcome of in-hospital mortality and need for invasive mechanical ventilation (IMV), respectively. There was no significant association between WHO BMI groups and these outcomes. Using Asia-Pacific cutoffs showed a significant association between obesity and in-hospital mortality risk (P = 0.012). Being underweight was an independent predictor of prolonged IMV requirement regardless of BMI criteria used (P < 0.01). Obesity correlated with the need for intensive care unit admission using Asia-Pacific cutoffs (P = 0.029). There was a significant association between any BMI abnormality and odds of severe/critical COVID-19 (P < 0.05). Obese patients with concomitant acute neurological presentation/diagnosis during their COVID-19 admission were shown to have lower odds of neurologic recovery (P < 0.05). We found BMI abnormalities to be associated with several adverse clinical and neurologic outcomes, although such associations may be more evident with the use of race-specific BMI criteria.
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体重指数类与2019年冠状病毒疾病的结合。
DOI：
10.1038/s41366-020-00721-1
发表时间：
2021-03
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Al-Salameh A;Lanoix JP;Bennis Y;Andrejak C;Brochot E;Deschasse G;Dupont H;Goeb V;Jaureguy M;Lion S;Maizel J;Moyet J;Vaysse B;Desailloud R;Ganry O;Schmit JL;Lalau JD
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DOI：
10.1007/s00702-021-02400-5
发表时间：
2021-11
期刊：
Journal of neural transmission (Vienna, Austria : 1996)
影响因子：
--
作者：
Espiritu AI;Sy MCC;Anlacan VMM;Jamora RDG;Philippine CORONA Study Group Investigators
通讯作者：
Philippine CORONA Study Group Investigators
DOI：
10.1002/oby.23111
发表时间：
2021-05
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Eastment MC;Berry K;Locke E;Green P;O'Hare A;Crothers K;Dominitz JA;Fan VS;Shah JA;Ioannou GN
通讯作者：
Ioannou GN
影响因子：
168.9
作者：
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通讯作者：
Yuen, Kwok-Yung
DOI：
10.1016/j.numecd.2020.07.047
发表时间：
2020-10-30
影响因子：
3.9
作者：
Biscarini, Simona;Colaneri, Marta;Mondelli, Mario U.
通讯作者：
Mondelli, Mario U.