Growing up with epilepsy: a two-year investigation of cognitive development in children with new onset epilepsy.
Growing up with epilepsy: a two-year investigation of cognitive development in children with new onset epilepsy.
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DOI：
10.1111/j.1528-1167.2008.01735.x
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发表时间：
2008-11
期刊：
影响因子：
5.6
通讯作者：
Seidenberg M
中科院分区：
文献类型：
--
作者：
Hermann BP;Jones JE;Sheth R;Koehn M;Becker T;Fine J;Allen CA;Seidenberg M
与健康对照组相比，描述新发癫痫儿童正常和异常认知发育的模式和决定因素。纵向（2年）认知增长进行了检查，在100名儿童，年龄8-18岁，包括健康对照组（n=48）和新发癫痫儿童（n=52）。认知成熟作为存在/不存在两种神经行为合并症（注意缺陷多动障碍和/或学业问题）的函数进行检查，在癫痫诊断时确定。通过评估智力、学业成绩、语言、记忆、执行功能和心理速度的综合神经心理电池对各组进行比较。无神经行为合并症的新发癫痫儿童在基线、认知发育率和所有神经心理学领域的随访评估方面与健康对照组相当。相比之下，神经行为合并症的存在与所有认知领域（尤其是执行功能）的基线和前瞻性认知轨迹显著恶化相关。癫痫发作时神经行为共病的存在是癫痫发作前后认知发育异常的主要标志。
To characterize patterns and determinants of normal and abnormal cognitive development in children with new onset epilepsy compared to healthy controls. Longitudinal (2-year) cognitive growth was examined in 100 children, age 8-18 years, including healthy controls (n=48) and children with new onset epilepsy (n=52). Cognitive maturation was examined as a function of the presence/absence of two neurobehavioral comorbitiies (Attention Deficit Hyperactivity Disorder and/or Academic Problems) identified at the time of epilepsy diagnosis. Groups were compared across a comprehensive neuropsychological battery assessing intelligence, academic achievement, language, memory, executive function and psychomotor speed. Children with new onset epilepsy without neurobehavioral comorbidities were comparable to healthy controls at baseline, rate of cognitive development, and follow-up assessment across all neuropsychological domains. In contrast, the presence of neurobehavioral comorbidities were associated with significantly worse baseline and prospective cognitive trajectories across all cognitive domains, especially executive functions. The presence of neurobehavioral comorbidities at the time of epilepsy onset is a major marker of abnormal cognitive development both prior to and after the onset of epilepsy.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
Dunn, DW;Austin, JK;Ambrosius, WT
通讯作者：
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影响因子：
1.9
作者：
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通讯作者：
Austin, Joan K.
影响因子：
2.6
作者：
Austin, JK;Dunn, DW;Perkins, SM
通讯作者：
Perkins, SM