Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.
Estrogen-producing endometrioid adenocarcinoma resembling sex cord-stromal tumor of the ovary: a review of four postmenopausal cases.
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DOI：
10.1186/1746-1596-7-164
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发表时间：
2012-11-28
影响因子：
2.6
通讯作者：
Sasano H
中科院分区：
文献类型：
--
作者：
Katoh T;Yasuda M;Hasegawa K;Kozawa E;Maniwa J;Sasano H
4例卵巢类性腺癌（EMA）表现为雌激素分泌过多，与性索间质肿瘤（SCST）相似。患者均为绝经后，年龄范围为60至79岁（平均年龄）。67.5），患者主诉腹部不适或腹胀以及非典型生殖器出血。细胞学检查可见宫颈阴道鳞状上皮成熟，子宫内膜增生活跃。术前发现血清雌激素（雌二醇，E2）值升高，范围为48.7至83.0 pg/mL（平均值）。58.4）。相反，卵泡刺激素被抑制到低于正常值。3例以实性生长为主，MRI诊断为颗粒细胞瘤或卵泡膜细胞瘤; 1例以囊实性结构为主，诊断为上皮性恶性肿瘤。3例实质部分大体呈均匀黄色。组织学上，除了常规EMA组织学外，不同数量的肿瘤成分排列在实心巢、中空小管、索状股和筛状巢中。综上所述，绝经后卵巢实体瘤有雌激素样表现者术前诊断为SCST。因此，在组织学诊断中，这种卵巢EMA变异可能具有挑战性，并因其形态学范围广泛而误诊为SCST。http://www.diagnosticpathology.diagnomx.eu/vs/6096841358065394
The 4 present cases with endometrioid adenocarcinoma (EMA) of the ovary were characterized by estrogen overproduction and resemblance to sex cord-stromal tumor (SCST). The patients were all postmenopausal, at ages ranging from 60 to 79 years (av. 67.5), who complained of abdominal discomfort or distention and also atypical genital bleeding. Cytologically, maturation of the cervicovaginal squamous epithelium and active endometrial proliferation were detected. The serum estrogen (estradiol, E2) value was preoperatively found to be elevated, ranging from 48.7 to 83.0 pg/mL (av. 58.4). In contrast, follicle stimulating hormone was suppressed to below the normal value. MR imaging diagnoses included SCSTs such as granulosa cell tumor or thecoma for 3 cases because of predominantly solid growth, and epithelial malignancy for one case because of cystic and solid structure. Grossly, the solid part of 3 cases was homogeneously yellow in color. Histologically, varying amounts of tumor components were arranged in solid nests, hollow tubules, cord-like strands and cribriform-like nests in addition to the conventional EMA histology. In summary, postmenopausal ovarian solid tumors with the estrogenic manifestations tend to be preoperatively diagnosed as SCST. Due to this, in the histological diagnosis, this variant of ovarian EMA may be challenging and misdiagnosed as SCST because of its wide range in morphology. http://www.diagnosticpathology.diagnomx.eu/vs/6096841358065394
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DOI：
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发表时间：
2010-04-01
影响因子：
1.6
作者：
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发表时间：
2007-06-01
影响因子：
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