High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies.
High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies.
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高血清尿酸与 2 型糖尿病风险增加：前瞻性队列研究的系统回顾和荟萃分析
DOI：
10.1371/journal.pone.0056864
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Lv Q;Meng XF;He FF;Chen S;Su H;Xiong J;Gao P;Tian XJ;Liu JS;Zhu ZH;Huang K;Zhang C
目的目前的证据表明，高血清尿酸可能增加2型糖尿病的风险，但其相关性仍不确定。该研究的目的是通过对前瞻性队列研究进行荟萃分析，评估血清尿酸与未来2型糖尿病风险之间的关系。设计和方法我们对PubMed数据库进行了系统的文献检索，直到2012年4月。前瞻性队列研究纳入荟萃分析，报告血清尿酸与2型糖尿病风险之间相关性的多变量校正相对风险（RR）和相应的95%置信区间（CI）。我们使用固定效应和随机效应模型来计算总体效应估计值。采用Q统计量和I2统计量检验研究间的异质性。使用Begg漏斗图和Egger回归检验评估潜在的发表偏倚。结果我们从8项前瞻性队列研究中检索到7篇符合条件的文章，共涉及32016例受试者和2930例2型糖尿病事件。血清尿酸水平最高与最低类别相比发生2型糖尿病的合并RR为1.56（95%CI，1.39-1.76）。剂量反应分析显示，血清尿酸水平每升高1 mg/dl，患2型糖尿病的风险增加6%（RR 1.06，95% CI：1.04-1.07）。每个亚组的结果显示血清尿酸与2型糖尿病风险之间存在显著相关性。在敏感性分析中，每次省略任何一项研究，组合RR都是一致的。几乎没有观察到异质性和发表偏倚的证据。结论前瞻性队列研究的荟萃分析提供了强有力的证据，表明高血清尿酸水平与其他已确定的危险因素，尤其是代谢综合征成分无关，是中老年人群发生2型糖尿病的危险因素。
Objective Current evidence suggests high serum uric acid may increase the risk of type 2 diabetes, but the association is still uncertain. The aim of the study was to evaluate the association between serum uric acid and future risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. Design and Methods We conducted a systematic literature search of the PubMed database through April 2012. Prospective cohort studies were included in meta-analysis that reported the multivariate adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) for the association between serum uric acid and risk of type 2 diabetes. We used both fix-effects and random-effects models to calculate the overall effect estimate. The heterogeneity across studies was tested by both Q statistic and I2 statistic. Begg’s funnel plot and Egger’s regression test were used to assess the potential publication bias. Results We retrieved 7 eligible articles derived from 8 prospective cohort studies, involving a total of 32016 participants and 2930 incident type 2 diabetes. The combined RR of developing type 2 diabetes for the highest category of serum uric acid level compared with the lowest was 1.56(95% CI, 1.39–1.76). Dose-response analysis showed the risk of type 2 diabetes was increased by 6% per 1 mg/dl increment in serum uric acid level (RR 1.06, 95% CI: 1.04–1.07). The result from each subgroup showed a significant association between serum uric acid and risk of type 2 diabetes. In sensitive analysis, the combined RR was consistent every time omitting any one study. Little evidence of heterogeneity and publication bias was observed. Conclusions Our meta-analysis of prospective cohort studies provided strong evidence that high level of serum uric acid is independent of other established risk factors, especially metabolic syndrome components, for developing type 2 diabetes in middle-aged and older people.
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影响因子：
19.6
作者：
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通讯作者：
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