Safety and efficacy of botulinum toxin type A in preventing and treating scars in animal models: A systematic review and meta-analysis.
Safety and efficacy of botulinum toxin type A in preventing and treating scars in animal models: A systematic review and meta-analysis.
复制标题
DOI：
10.1111/iwj.13673
复制
发表时间：
2022-05
影响因子：
3.1
通讯作者：
Zhang, Lianbo
中科院分区：
文献类型：
--
作者：
Pan, Lingfeng;Qin, Haiyan;Li, Caihong;Yang, Liehao;Li, Mingxi;Kong, Jiao;Zhang, Guang;Zhang, Lianbo
以往的研究已经使用A型肉毒毒素（BTXA）来改善术后和增生性瘢痕;然而，缺乏对这种方法的安全性和有效性的详细验证。本研究旨在评价BTXA对手术后增生性瘢痕的治疗作用及其对细胞因子表达的影响。对不同数据库进行了计算机检索，包括PubMed、Web of Science、Scopus、科克伦、Embase、CNKI和万方，检索时间截止至2021年3月10日。基于肥大指数、上皮形成时间、伤口面积和血管内皮生长因子（VEGF）表达，使用R 4.0.0进行Meta分析。纳入了11项研究。Meta分析显示，肥大指数（标准化平均差[SMD] =-2.63，95%置信区间[CI]：-3.50至-1.76，P < .01），伤口面积（SMD =-0.54，95%CI：-1.24至0.16，P < .01）和VEGF表达（SMD =-2.56，95%CI：-3.50至1.62，P < .01）。本研究表明，BTXA在动物模型中预防和治疗瘢痕增生是安全有效的，但应避免过量使用BTXA和BTXA治疗大面积。
Previous studies have used botulinum toxin type A (BTXA) to improve postoperative and hypertrophic scars; however, there is lack of detailed verification on the safety and effectiveness of this approach. This study aimed to evaluate the therapeutic effect of BTXA on postoperative hypertrophic scars and its influence on cytokine expression in animal models. A computerised search of different databases was performed, including PubMed, Web of Science, Scopus, Cochrane, Embase, CNKI, and Wanfang, up to 10 March 2021. A meta‐analysis was performed using R 4.0.0 based on hypertrophic index, epithelialisation time, wound area, and vascular endothelial growth factor (VEGF) expression. Eleven studies were included. The meta‐analysis showed a significant difference in hypertrophic index (standardised mean difference [SMD] = −2.63, 95% confidence interval [CI]: −3.50 to −1.76, P < .01), wound area (SMD = −0.54, 95% CI: −1.24 to 0.16, P < .01), and VEGF expression (SMD = −2.56, 95% CI: −3.50 to −1.62, P < .01). This study shows that BTXA is safe and effective in preventing and treating scar hypertrophy in animal models, but excessive doses of BTXA and BTXA to treat large areas should be avoided.
登录
查看更多内容
影响因子：
2.4
作者：
Berman, Brian;Maderal, Andrea;Raphael, Brian
通讯作者：
Raphael, Brian
影响因子：
8.9
作者：
Gassner, Holger G.;Brissett, Anthony E.;Sherris, David A.
通讯作者：
Sherris, David A.
DOI：
10.1111/wrr.12839
发表时间：
2020-09
期刊：
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
影响因子：
--
作者：
Nischwitz SP;Rauch K;Luze H;Hofmann E;Draschl A;Kotzbeck P;Kamolz LP
通讯作者：
Kamolz LP
影响因子：
3
作者：
Lee BJ;Jeong JH;Wang SG;Lee JC;Goh EK;Kim HW
通讯作者：
Kim HW
影响因子：
3.6
作者：
Gassner, HG;Sherris, DA;Otley, CC
通讯作者：
Otley, CC