Gut microbiota: a non-target victim of pesticide-induced toxicity.
Gut microbiota: a non-target victim of pesticide-induced toxicity.
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DOI：
10.1080/19490976.2023.2187578
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发表时间：
2023-01
期刊：
影响因子：
12.2
通讯作者：
中科院分区：
文献类型：
--
作者：
由于接触包括农药在内的各种环境污染物，人类肠道微生物群可能会受到破坏。这些污染物以多种方式进入非目标物种并造成潜在的健康风险。肠道微生物群衍生的代谢物通过调节代谢稳态在维持宿主健康方面发挥着重要作用。这种体内平衡的不平衡会导致各种疾病的发生及其发病机制。农药对宿主肠道微生物群有有害影响，这在最近的一些研究中很明显。因此，迫切需要探索农药对宿主肠道微生物介导的代谢变化的影响，这可能有助于更好地了解农药引起的毒性。本综述总结了农药对肠道微生物群的影响，进而引起次生代谢物释放的变化，从而可能导致各种宿主健康影响。
The human gut microbiota can be potentially disrupted due to exposure of various environmental contaminants, including pesticides. These contaminants enter into non-target species in multiple ways and cause potential health risks. The gut microbiota-derived metabolites have a significant role in maintaining the host’s health by regulating metabolic homeostasis. An imbalance in this homeostasis can result in the development of various diseases and their pathogenesis. Pesticides have hazardous effects on the host’s gut microbiota, which is evident in a few recent studies. Therefore, there is an urgent need to explore the effect of pesticide on gut microbiota-mediated metabolic changes in the host, which may provide a better understanding of pesticide-induced toxicity. The present review summarizes the pesticide-induced effects on gut microbiota, which in turn, induces changes in the release of their secondary metabolites that could lead to various host health effects.
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