A research agenda to underpin malaria eradication.
A research agenda to underpin malaria eradication.
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DOI：
10.1371/journal.pmed.1000406
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发表时间：
2011-01-25
期刊：
影响因子：
15.8
通讯作者：
Tanner M
中科院分区：
文献类型：
--
作者：
Alonso PL;Brown G;Arevalo-Herrera M;Binka F;Chitnis C;Collins F;Doumbo OK;Greenwood B;Hall BF;Levine MM;Mendis K;Newman RD;Plowe CV;Rodríguez MH;Sinden R;Slutsker L;Tanner M
Pedro Alonso和他的同事介绍了根除疟疾研究议程(Malera)倡议和发表在这本《公共科学图书馆·医学增刊》上的一组文章，这些文章提炼了对根除疟疾至关重要的研究问题。全球疟疾传播的阻断是国际卫生界和发展界面临的最大挑战之一。目前的专家观点认为，通过利用现有的工具和战略积极加强控制，可以在防治疟疾方面取得更大的成果，包括在一些国家和地区消灭疟疾；然而，即使作出最大努力，我们也达不到全球根除疟疾的目标。《根除疟疾研究议程》是对目前的研究议程的补充，主要目的是减少发病率和死亡率，目的是找出关键的知识差距，并确定将导致基本繁殖率降至1以下的战略和工具，最终目标是从人类人口中根除这种寄生虫。地方社区、民间社会、政策领导人和科学界的持续承诺，以及为建立来自疫区的强大研究人员基础所作的巨大努力，将是这一新议程取得成功的关键因素。
Pedro Alonso and colleagues introduce the Malaria Eradication Research Agenda (malERA) initiative and the set of articles published in this PLoS Medicine Supplement that distill the research questions key to malaria eradication. The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scaling up control with currently available tools and strategies, much greater gains could be achieved against malaria, including elimination from a number of countries and regions; however, even with maximal effort we will fall short of global eradication. The Malaria Eradication Research Agenda (malERA) complements the current research agenda—primarily directed towards reducing morbidity and mortality—with one that aims to identify key knowledge gaps and define the strategies and tools that will result in reducing the basic reproduction rate to less than 1, with the ultimate aim of eradication of the parasite from the human population. Sustained commitment from local communities, civil society, policy leaders, and the scientific community, together with a massive effort to build a strong base of researchers from the endemic areas will be critical factors in the success of this new agenda.
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