Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection.
Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection.
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DOI：
10.1038/s41590-021-01089-8
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发表时间：
2022-01
影响因子：
30.5
通讯作者：
Ladhani S
中科院分区：
文献类型：
--
作者：
Dowell AC;Butler MS;Jinks E;Tut G;Lancaster T;Sylla P;Begum J;Bruton R;Pearce H;Verma K;Logan N;Tyson G;Spalkova E;Margielewska-Davies S;Taylor GS;Syrimi E;Baawuah F;Beckmann J;Okike IO;Ahmad S;Garstang J;Brent AJ;Brent B;Ireland G;Aiano F;Amin-Chowdhury Z;Jones S;Borrow R;Linley E;Wright J;Azad R;Waiblinger D;Davis C;Thomson EC;Palmarini M;Willett BJ;Barclay WS;Poh J;Amirthalingam G;Brown KE;Ramsay ME;Zuo J;Moss P;Ladhani S
儿童中的 SARS-CoV-2 感染通常较轻或无症状，但这一结果的生物学基础尚不清楚。在这里，我们比较儿童（3-11 岁）和成人的抗体和细胞免疫。儿童中针对刺突蛋白的抗体反应较高，血清转化通过 S2 结构域的交叉识别增强了针对季节性 β 冠状病毒的反应。儿童和成人之间病毒变体的中和效果相当。儿童中的尖峰特异性 T 细胞反应是儿童的两倍多，并且在许多血清阴性儿童中也检测到，这表明预先存在对季节性冠状病毒的交叉反应。重要的是，儿童在感染后 6 个月仍保留抗体和细胞反应，而成人则相对减弱。超过 12 个月后，尖峰特异性反应也基本稳定。因此，儿童对 SARS-CoV-2 产生强烈、交叉反应和持续的免疫反应，且对刺突蛋白具有特异性。这些发现提供了对大多数儿童的相对临床保护的深入了解，并可能有助于指导儿科疫苗接种方案的设计。 SARS-CoV-2 感染在儿童中较轻，但与成人直接比较的情况很少。作者在此表明，儿童的免疫反应更高，可以保留 12 个月或更长时间，并且可以中和 Alpha、Beta 和 Delta 变异。
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3–11 years) and adults. Antibody responses against spike protein were high in children and seroconversion boosted responses against seasonal Beta-coronaviruses through cross-recognition of the S2 domain. Neutralization of viral variants was comparable between children and adults. Spike-specific T cell responses were more than twice as high in children and were also detected in many seronegative children, indicating pre-existing cross-reactive responses to seasonal coronaviruses. Importantly, children retained antibody and cellular responses 6 months after infection, whereas relative waning occurred in adults. Spike-specific responses were also broadly stable beyond 12 months. Therefore, children generate robust, cross-reactive and sustained immune responses to SARS-CoV-2 with focused specificity for the spike protein. These findings provide insight into the relative clinical protection that occurs in most children and might help to guide the design of pediatric vaccination regimens. SARS-CoV-2 infection is milder in children, but direct comparison with adults is rare. Here the authors show that immune responses are higher in children, retained for 12 months or longer and can neutralize Alpha, Beta and Delta variants.
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影响因子：
9.8
作者：
Rihn SJ;Merits A;Bakshi S;Turnbull ML;Wickenhagen A;Alexander AJT;Baillie C;Brennan B;Brown F;Brunker K;Bryden SR;Burness KA;Carmichael S;Cole SJ;Cowton VM;Davies P;Davis C;De Lorenzo G;Donald CL;Dorward M;Dunlop JI;Elliott M;Fares M;da Silva Filipe A;Freitas JR;Furnon W;Gestuveo RJ;Geyer A;Giesel D;Goldfarb DM;Goodman N;Gunson R;Hastie CJ;Herder V;Hughes J;Johnson C;Johnson N;Kohl A;Kerr K;Leech H;Lello LS;Li K;Lieber G;Liu X;Lingala R;Loney C;Mair D;McElwee MJ;McFarlane S;Nichols J;Nomikou K;Orr A;Orton RJ;Palmarini M;Parr YA;Pinto RM;Raggett S;Reid E;Robertson DL;Royle J;Cameron-Ruiz N;Shepherd JG;Smollett K;Stewart DG;Stewart M;Sugrue E;Szemiel AM;Taggart A;Thomson EC;Tong L;Torrie LS;Toth R;Varjak M;Wang S;Wilkinson SG;Wyatt PG;Zusinaite E;Alessi DR;Patel AH;Zaid A;Wilson SJ;Mahalingam S
通讯作者：
Mahalingam S
影响因子：
16.6
作者：
Bates TA;Leier HC;Lyski ZL;McBride SK;Coulter FJ;Weinstein JB;Goodman JR;Lu Z;Siegel SAR;Sullivan P;Strnad M;Brunton AE;Lee DX;Adey AC;Bimber BN;O'Roak BJ;Curlin ME;Messer WB;Tafesse FG
通讯作者：
Tafesse FG
影响因子：
9.4
作者：
Dijkman, Ronald;Jebbink, Maarten F.;van der Hoek, Lia
通讯作者：
van der Hoek, Lia
DOI：
10.1128/cdli.12.11.1317-1321.2005
发表时间：
2005-11-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Chan, KH;Cheng, VCC;Peiris, JSM
通讯作者：
Peiris, JSM
DOI：
10.1016/j.lanepe.2021.100075
发表时间：
2021-04
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Flood J;Shingleton J;Bennett E;Walker B;Amin-Chowdhury Z;Oligbu G;Avis J;Lynn RM;Davis P;Bharucha T;Pain CE;Jyothish D;Whittaker E;Dwarakanathan B;Wood R;Williams C;Swann O;Semple MG;Ramsay ME;Jones CE;Ramanan AV;Gent N;Ladhani SN
通讯作者：
Ladhani SN