Biochemistry of epidermal stem cells.
Biochemistry of epidermal stem cells.
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DOI：
10.1016/j.bbagen.2012.07.002
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发表时间：
2013-02
影响因子：
3
通讯作者：
Kerr, Candace
中科院分区：
文献类型：
--
作者：
Eckert, Richard L.;Adhikary, Gautam;Balasubramanian, Sivaprakasam;Rorke, Ellen A.;Vemuri, Mohan C.;Boucher, Shayne E.;Bickenbach, Jackie R.;Kerr, Candace
表皮是维持生命所必需的重要保护屏障。维持这种屏障需要持续的细胞增殖和分化。此外，这些过程必须平衡以产生正常的表皮。表皮干细胞位于基底表皮、毛囊和皮脂腺中的特定位置，这些细胞负责补充该组织。大量的努力已经进入到确定蛋白质表位标记干细胞，在确定干细胞的利基位置，并在了解干细胞群体是如何相关的。我们讨论这些研究，因为它们适用于了解正常表皮稳态和皮肤癌。分类的干细胞标志物已被确定，允许分配的干细胞的特定区域的表皮，并取得了进展，在理解这些细胞在正常的表皮稳态和组织应力的条件下的作用。一个关键的发现是表皮中存在多种干细胞群，这些干细胞群产生不同的结构，并且多种干细胞类型可能有助于修复受损的表皮。了解表皮干细胞生物学可能会导致治疗皮肤病和癌症的重要疗法，也将有助于我们了解其他系统中的干细胞。这篇文章是题为干细胞生物化学的特刊的一部分。
The epidermis is an important protective barrier that is essential for maintenance of life. Maintaining this barrier requires continuous cell proliferation and differentiation. Moreover, these processes must be balanced to produce a normal epidermis. The stem cells of the epidermis reside in specific locations in the basal epidermis, hair follicle and sebaceous glands and these cells are responsible for replenishment of this tissue. A great deal of effort has gone into identifying protein epitopes that mark stem cells, in identifying stem cell niche locations, and in understanding how stem cell populations are related. We discuss these studies as they apply to understanding normal epidermal homeostasis and skin cancer. An assortment of stem cell markers have been identified that permit assignment of stem cells to specific regions of the epidermis, and progress has been made in understanding the role of these cells in normal epidermal homeostasis and in conditions of tissue stress. A key finding is the multiple stem cell populations exist in epidermis that give rise to different structures, and that multiple stem cell types may contribute to repair in damaged epidermis. Understanding epidermal stem cell biology is likely to lead to important therapies for treating skin diseases and cancer, and will also contribute to our understanding of stem cells in other systems. This article is part of a Special Issue entitled Biochemistry of Stem Cells.
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DOI：
10.1111/j.1365-2184.1986.tb00684.x
发表时间：
1986-05-01
期刊：
CELL AND TISSUE KINETICS
影响因子：
--
作者：
BICKENBACH, JR;MCCUTECHEON, J;MACKENZIE, IC
通讯作者：
MACKENZIE, IC
影响因子：
5.2
作者：
Baxter, MA;Wynn, RF;Bellantuono, I
通讯作者：
Bellantuono, I
DOI：
10.1111/j.1610-0387.2005.05037.x
发表时间：
2005-07-01
期刊：
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
影响因子：
--
作者：
Boukamp, Petra
通讯作者：
Boukamp, Petra
DOI：
10.1111/j.1087-0024.2004.09313.x
发表时间：
2004-09-01
影响因子：
--
作者：
Braun, KM;Watt, FM
通讯作者：
Watt, FM
影响因子：
6.5
作者：
Antonini, Dario;Russo, Monia T.;Missero, Caterina
通讯作者：
Missero, Caterina