Prenatal and postnatal correlates of moderate-to-vigorous physical activity in midlife: evidence from the 1970 British Cohort Study
Prenatal and postnatal correlates of moderate-to-vigorous physical activity in midlife: evidence from the 1970 British Cohort Study
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DOI：
10.1136/jech-2022-219213
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发表时间：
2022-09-09
影响因子：
6.3
通讯作者：
Hamer, Mark
中科院分区：
文献类型：
--
作者：
Blodgett, Joanna M.;Norris, Thomas;Stamatakis, Emmanuel;O'Donovan, Gary;Pinto Pereira, Snehal M.;Hamer, Mark
据推测，终身体育活动的行为是建立在生命的早期，但有最小的，矛盾的，证据检查产前和产后因素与成年体育活动。我们调查了前瞻性确定的产前/产后因素与中年时设备测量的中度至剧烈体力活动（MVPA）之间的关联。分析包括来自1970年英国队列研究的5011名参与者，这是一项针对同一周内出生的个体的出生队列研究。在出生时，确定了以下因素：社会经济地位（SEP），母亲年龄，以前怀孕的次数，母亲吸烟，母亲糖尿病，孕龄，出生体重，母乳喂养状况和婴儿健康问题。MVPA是在46岁时用大腿佩戴的加速度计设备按照24小时协议在7天内捕获的。在性别调整模型中，SEP降低（−6.7分钟/天（95% CI：−9.0至-4.4）在父亲从事半技术或非技术职业的妇女中），（母亲年龄每增加一年，0.4分钟/天（0.2至0.5）），母亲在怀孕期间吸烟（−2.5分钟/天（−4.0至-1.0））和足月后胎龄（−7.4分钟/天（−11.5至-3.4）;仅男孩）与46岁时MVPA较低相关。在相互调整的模型中，相关性没有改变，但有一些证据表明出生体重也可能与MVPA水平相关。SEP、母亲年龄、母亲吸烟、男孩足月分娩和出生体重与中年MVPA相关，表明中年体力活动行为可能在出生时部分建立。在不利环境中的早期干预可能对整个生命过程中的身体活动产生积极影响。
It is hypothesised that lifelong physical activity behaviours are established in early life, however there is minimal, and contradictory, evidence examining prenatal and postnatal factors in relation to adulthood physical activity. We investigated associations between prospectively ascertained prenatal/postnatal factors and device-measured moderate-to-vigorous physical activity (MVPA) in midlife. Analyses included 5011 participants from the 1970 British Cohort Study, a birth cohort study of individuals born within the same week. At birth, the following factors were ascertained: socioeconomic position (SEP), maternal age, number of previous pregnancies, maternal smoking, maternal diabetes, gestational age, birth weight, breastfeeding status and infant health concerns. MVPA was captured at age 46 with a thigh-worn accelerometer device following a 24-hour protocol over 7 days. In sex-adjusted models, lower SEP (−6.7 min/day (95% CI: −9.0 to –4.4) in those with a partly or unskilled paternal occupation), younger maternal age (0.4 min/day (0.2 to 0.5) per additional year of maternal age), maternal smoking during pregnancy (−2.5 min/day (−4.0 to –1.0)) and post-term gestational age (−7.4 min/day (−11.5 to –3.4); boys only) were associated with lower MVPA at age 46. In the mutually adjusted model, associations did not change but there was some evidence that birth weight may also be associated with MVPA levels. SEP, maternal age, maternal smoking, post-term birth in boys and birth weight were associated with MVPA in midlife, indicating that midlife physical activity behaviours may be partially established at birth. Early interventions in disadvantaged environments may have a positive impact on physical activity throughout the life course.
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