microRNA function in left-right neuronal asymmetry: perspectives from C. elegans.
microRNA function in left-right neuronal asymmetry: perspectives from C. elegans.
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DOI：
10.3389/fncel.2013.00158
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发表时间：
2013-09-23
影响因子：
5.3
通讯作者：
Chuang CF
中科院分区：
文献类型：
--
作者：
Alqadah A;Hsieh YW;Chuang CF
神经系统的解剖结构和功能的左右不对称性存在于整个动物王国。例如，语言中心位于人类大脑的左侧，而大多数人的空间识别功能位于右半球。神经系统不对称性的破坏与神经系统疾病相关。虽然在哺乳动物神经系统中观察到解剖和功能不对称，但确定这些不对称的分子基础一直是一个挑战。C.线虫已经成为研究神经系统中分子不对称性的主要模式生物，因为它已经显示出与生物学相关分子的不对称分布和调节明显相关的功能不对称性。小的非编码RNA最近被牵连在神经发育的各个方面。在这里，我们回顾的情况下，microRNA是至关重要的建立左右不对称的C。线虫的神经系统这些研究可能会深入了解分子和功能不对称是如何在人类大脑中建立的。
Left–right asymmetry in anatomical structures and functions of the nervous system is present throughout the animal kingdom. For example, language centers are localized in the left side of the human brain, while spatial recognition functions are found in the right hemisphere in the majority of the population. Disruption of asymmetry in the nervous system is correlated with neurological disorders. Although anatomical and functional asymmetries are observed in mammalian nervous systems, it has been a challenge to identify the molecular basis of these asymmetries. C. elegans has emerged as a prime model organism to investigate molecular asymmetries in the nervous system, as it has been shown to display functional asymmetries clearly correlated to asymmetric distribution and regulation of biologically relevant molecules. Small non-coding RNAs have been recently implicated in various aspects of neural development. Here, we review cases in which microRNAs are crucial for establishing left–right asymmetries in the C. elegans nervous system. These studies may provide insight into how molecular and functional asymmetries are established in the human brain.
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