Diffusion kurtosis imaging and high-resolution MRI demonstrate structural aberrations of caudate putamen and amygdala after chronic mild stress.
Diffusion kurtosis imaging and high-resolution MRI demonstrate structural aberrations of caudate putamen and amygdala after chronic mild stress.
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DOI：
10.1371/journal.pone.0095077
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Van der Linden A
中科院分区：
文献类型：
--
作者：
Delgado y Palacios R;Verhoye M;Henningsen K;Wiborg O;Van der Linden A
重度抑郁症（MDD）和其他应激相关疾病的病理生理学与海马和额叶脑区的畸变有关。最近，其他大脑区域，如尾状核，壳核和杏仁核也被认为在情绪障碍的发展中发挥作用。通过将大鼠暴露于各种应激源超过8周，可以基于蔗糖消耗试验来区分不同的表型，即应激易感（快感缺失样）和应激弹性动物。快感缺失样动物是MDD的良好验证模型。以前，我们报告说，在体内扩散峰度成像（DKI）的海马显示改变扩散特性在慢性应激大鼠独立的享乐状态和右海马的形状是不同的三个组，包括未受到挑战的控制。在这项研究中，我们评估了扩散性能的前额叶皮层，尾壳核（CPU）和杏仁核的快感缺失和弹性的表型，并发现，平均峰度在CPU是显着不同的快感缺失和弹性的动物。此外，轴向扩散和径向扩散增加，在应激动物组中的CPu和杏仁核，分别。此外，我们发现，CPu/脑体积比显着增加，与对照动物相比，在快感缺失样动物。同时，我们的研究结果表明，慢性应激对大脑的影响并不是在这些区域偏侧的。这些发现证实了CPu和杏仁核参与应激相关疾病和MDD。此外，我们还表明，DKI是一个潜在的重要工具，以促进客观评估精神疾病。
The pathophysiology of major depressive disorder (MDD) and other stress related disorders has been associated with aberrations in the hippocampus and the frontal brain areas. More recently, other brain regions, such as the caudate nucleus, the putamen and the amygdala have also been suggested to play a role in the development of mood disorders. By exposing rats to a variety of stressors over a period of eight weeks, different phenotypes, i.e. stress susceptible (anhedonic-like) and stress resilient animals, can be discriminated based on the sucrose consumption test. The anhedonic-like animals are a well validated model for MDD. Previously, we reported that in vivo diffusion kurtosis imaging (DKI) of the hippocampus shows altered diffusion properties in chronically stressed rats independent of the hedonic state and that the shape of the right hippocampus is differing among the three groups, including unchallenged controls. In this study we evaluated diffusion properties in the prefrontal cortex, caudate putamen (CPu) and amygdala of anhedonic-like and resilient phenotypes and found that mean kurtosis in the CPu was significantly different between the anhedonic-like and resilient animals. In addition, axial diffusion and radial diffusion were increased in the stressed animal groups in the CPu and the amygdala, respectively. Furthermore, we found that the CPu/brain volume ratio was increased significantly in anhedonic-like animals as compared with control animals. Concurrently, our results indicate that the effects of chronic stress on the brain are not lateralized in these regions. These findings confirm the involvement of the CPu and the amygdala in stress related disorders and MDD. Additionally, we also show that DKI is a potentially important tool to promote the objective assessment of psychiatric disorders.
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DOI：
10.1176/appi.ajp.2008.08081201
发表时间：
2009-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Pizzagalli DA;Holmes AJ;Dillon DG;Goetz EL;Birk JL;Bogdan R;Dougherty DD;Iosifescu DV;Rauch SL;Fava M
通讯作者：
Fava M
影响因子：
3.7
作者：
Blood AJ;Iosifescu DV;Makris N;Perlis RH;Kennedy DN;Dougherty DD;Kim BW;Lee MJ;Wu S;Lee S;Calhoun J;Hodge SM;Fava M;Rosen BR;Smoller JW;Gasic GP;Breiter HC;Phenotype Genotype Project on Addiction and Mood Disorders
通讯作者：
Phenotype Genotype Project on Addiction and Mood Disorders
影响因子：
4.4
作者：
Helpern, Joseph A.;Adisetiyo, Vitria;Falangola, Maria F.;Hu, Caixia;Di Martino, Adriana;Williams, Kathleen;Castellanos, Francisco X.;Jensen, Jens H.
通讯作者：
Jensen, Jens H.
影响因子：
3.1
作者：
Bergstroem, A.;Jayatissa, M. N.;Wiborg, O.
通讯作者：
Wiborg, O.
影响因子：
4.4
作者：
Falangola, Maria F.;Jensen, Jens H.;Babb, James S.;Hu, Caixia;Castellanos, Francisco X.;Di Martino, Adriana;Ferris, Steven H.;Helpern, Joseph A.
通讯作者：
Helpern, Joseph A.