A population-based case-control study of extreme summer temperature and birth defects.
A population-based case-control study of extreme summer temperature and birth defects.
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DOI：
10.1289/ehp.1104671
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发表时间：
2012-10
影响因子：
10.4
通讯作者：
Hwang SA
中科院分区：
文献类型：
--
作者：
Van Zutphen AR;Lin S;Fletcher BA;Hwang SA
背景：虽然体温过高是公认的动物致畸因素，母体发热与人类出生缺陷有关，但有关环境高温与出生缺陷之间关系的数据有限。目的：为了确定妊娠是否可能容易受到气候变化预期的极端天气的影响，我们评估了极端夏季温度与出生缺陷发生的关系。方法：我们进行了一项基于人群的病例对照研究，将纽约州先天性畸形登记处与1992-2006年的出生证明联系起来。我们从随机抽取的10%活产婴儿中选择了非畸形婴儿作为对照。我们分配了基于出生时母亲住所的气象数据，总结了胚胎发育关键期的普遍表观温度(UAT；华氏度)，并使用多变量Logistic回归估计了调整后的优势比(AOR)和95%可信区间(CI)，控制了出生证明上的混杂因素。结果：在6,422例患者和59,328例对照组中，平均每日最小UAT增加5度与先天性白内障显著相关(AOR=1.51；95%CI：1.14，1.99)。先天性白内障也与所有环境温度指标显著相关：热浪、热浪次数和超过90%百分位数的天数。肾发育不全/发育不全(阳性)和无眼症/小眼炎和腹裂(阴性)与体温指标子集的相关性不一致。结论：我们发现在相关发育窗口期的多个体温指标与先天性白内障之间存在正相关且一致的关联，这一点应该得到其他数据来源的证实。
Background: Although hyperthermia is a recognized animal teratogen and maternal fever has been associated with birth defects in humans, data on the relationship between high environmental temperatures and birth defects are limited. Objective: To determine whether pregnancies are potentially vulnerable to the weather extremes anticipated with climate change, we evaluated the relationship between extreme summer temperature and the occurrence of birth defects. Methods: We performed a population-based case–control study by linking the New York State Congenital Malformations Registry to birth certificates for the years 1992–2006. We selected nonmalformed infants from a 10% random sample of live births as controls. We assigned meteorologic data based on maternal residence at birth, summarized universal apparent temperature (UAT; degrees Fahrenheit) across the critical period of embryogenesis, and estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) with multivariable logistic regression, controlling for confounders available on the birth certificate. Results: Among 6,422 cases and 59,328 controls that shared at least 1 week of the critical period in summer, a 5-degree increase in mean daily minimum UAT was significantly associated with congenital cataracts (aOR = 1.51; 95% CI: 1.14, 1.99). Congenital cataracts were significantly associated with all ambient temperature indicators as well: heat wave, number of heat waves, and number of days above the 90th percentile. Inconsistent associations with a subset of temperature indicators were observed for renal agenesis/hypoplasia (positive) and anophthalmia/microphthalmia and gastroschisis (negative). Conclusions: We found positive and consistent associations between multiple heat indicators during the relevant developmental window and congenital cataracts which should be confirmed with other data sources.
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DOI：
10.1002/bdra.20646
发表时间：
2010-03-01
影响因子：
--
作者：
Hashmi, S. Shahrukh;Gallaway, M. Shayne;Hecht, Jacqueline T.
通讯作者：
Hecht, Jacqueline T.
影响因子：
2.8
作者：
Judge, CM;Chasan-Taber, L;Marshall, EG
通讯作者：
Marshall, EG
DOI：
10.1002/bdra.20369
发表时间：
2007-07-01
影响因子：
--
作者：
Czeizel, Andrew E.;Puho, Erzsebet H.;Banhidy, Ferenc
通讯作者：
Banhidy, Ferenc
影响因子：
12.7
作者：
Honein, MA;Paulozzi, LJ
通讯作者：
Paulozzi, LJ
影响因子：
120.7
作者：
MILUNSKY, A;ULCICKAS, M;JICK, H
通讯作者：
JICK, H