Characteristics of Glutamate-Evoked Pain in the Masseter Region: Differences Between Targeted Injections in Subcutaneous, Muscle, and Bone Tissues.
Characteristics of Glutamate-Evoked Pain in the Masseter Region: Differences Between Targeted Injections in Subcutaneous, Muscle, and Bone Tissues.
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咬肌区谷氨酸诱发疼痛的特征：皮下、肌肉和骨组织靶向注射之间的差异。
DOI：
10.11607/ofph.2042
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Udagawa G
中科院分区：
文献类型：
--
作者：
藤田和歌子、横手未仁;植田弘師;Lakshmi Devi;Udagawa G
目的：研究咬肌区谷氨酸诱发的疼痛是否在三种不同注射深度之间存在差异，靶向皮下、肌肉和骨组织。研究方法：共有16名健康志愿者参与，并以随机顺序在咬肌区域接受谷氨酸盐（1.0 M，0.2 mL）和等渗盐水（0.9%，0.2 mL）注射，靶向皮下、肌内和骨表面组织。注射后，使用电子视觉模拟量表（eVAS）和不愉快、疲劳、紧张、疼痛和僵硬的数字评定量表（NRS）评分测量疼痛强度。还评估了压痛敏感性（PPS）、疼痛绘图区域和麦吉尔疼痛问卷（MPQ）评分。采用重复测量方差分析、McNemar检验和Tukey事后检验进行统计分析。P <. 05被认为具有统计学显著性。结果如下：总的来说，皮下注射比肌内注射引起更多的不愉快和疼痛，在骨表面注射谷氨酸后诱发的PPS评分显著高于肌内注射谷氨酸后。皮下注射谷氨酸盐更常被描述为”尖锐”和”挤压“。“结论：皮下注射比肌肉注射更痛苦和不愉快。在骨表面注射谷氨酸使深部疼痛组织对压力刺激敏感。临床上，可能很难区分咬肌区疼痛的来源或部位，但特定的质量和文字描述可以帮助鉴别诊断。
Aims: To investigate whether glutamate-evoked pain in the masseter region differs between three different depths of injection, targeting subcutaneous, muscle, and bone tissues. Methods: A total of 16 healthy volunteers participated and, in a randomized order, received injections of glutamate (1.0 M, 0.2 mL) and isotonic saline (0.9%, 0.2 mL) in the masseter region that targeted subcutaneous, intramuscular, and bone surface tissues. Following injection, pain intensity was measured using electronic visual analog scale (eVAS) and numeric rating scale (NRS) scores of unpleasantness, tiredness, tension, soreness, and stiffness. Pressure pain sensitivity (PPS), pain drawing areas, and McGill Pain Questionnaire (MPQ) scores were also assessed. Repeated-measures analysis of variance, McNemar test, and Tukey post hoc tests were used for statistical analyses. P <. 05 was considered statistically significant. Results: Overall, subcutaneous injections induced significantly more unpleasantness and pain than intramuscular injections, and PPS scores evoked after glutamate injection at the surface of the bone were significantly higher than after intramuscular glutamate injection. Subcutaneous glutamate injections were more often described as" sharp" and" pinching." Conclusion: The subcutaneous injection was more painful and unpleasant than the intramuscular injection. The glutamate injection at the surface of the bone sensitized the deep pain tissues to pressure stimulation. Clinically, it may be difficult to differentiate between the source or site of pain originating from the masseter region, but the specific quality and word descriptors could assist in differential diagnosis.
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影响因子：
2.5
作者：
Schiffman E;Ohrbach R;Truelove E;Look J;Anderson G;Goulet JP;List T;Svensson P;Gonzalez Y;Lobbezoo F;Michelotti A;Brooks SL;Ceusters W;Drangsholt M;Ettlin D;Gaul C;Goldberg LJ;Haythornthwaite JA;Hollender L;Jensen R;John MT;De Laat A;de Leeuw R;Maixner W;van der Meulen M;Murray GM;Nixdorf DR;Palla S;Petersson A;Pionchon P;Smith B;Visscher CM;Zakrzewska J;Dworkin SF;International RDC/TMD Consortium Network, International association for Dental Research;Orofacial Pain Special Interest Group, International Association for the Study of Pain
通讯作者：
Orofacial Pain Special Interest Group, International Association for the Study of Pain
疼痛绘图分数与疼痛描述和功能评级的关系。
DOI：
10.1097/00002508-199112000-00004
发表时间：
1991
期刊：
The Clinical journal of pain
影响因子：
--
作者：
T. Toomey;J. Mann;S. Abashian;S. Thompson
通讯作者：
S. Thompson
肌内温度调节人类谷氨酸引起的咬肌疼痛强度。
影响因子：
2.5
作者：
Hitoshi Sato;E. Castrillon;B. Cairns;K. Bendixen;Kelun Wang;T. Nakagawa;K. Wajima;P. Svensson
通讯作者：
P. Svensson
影响因子：
7.6
作者：
Futarmal, S.;Kothari, M.;Svensson, P.
通讯作者：
Svensson, P.
DOI：
10.1186/s10194-015-0546-0
发表时间：
2015
期刊：
The journal of headache and pain
影响因子：
--
作者：
Shimada A;Castrillon E;Baad-Hansen L;Ghafouri B;Gerdle B;Ernberg M;Cairns B;Svensson P
通讯作者：
Svensson P