A multifunctional SN38-conjugated nanosystem for defeating myelosuppression and diarrhea induced by irinotecan in esophageal cancer.
A multifunctional SN38-conjugated nanosystem for defeating myelosuppression and diarrhea induced by irinotecan in esophageal cancer.
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一种多功能 SN38 共轭纳米系统，用于克服伊立替康在食管癌中引起的骨髓抑制和腹泻
DOI：
10.1039/d0nr06266a
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发表时间：
2020-10
期刊：
影响因子：
6.7
通讯作者：
Dong C
中科院分区：
文献类型：
--
作者：
Chen J;Zhou L;Wang C;Sun Y;Lu Y;Li R;Hu X;Chen M;Chen L;Chai K;Yao T;Shi S;Dong C
A combination of chemotherapy and phototherapy has been proposed as a promising treatment for esophageal cancer (EC). Irinotecan as a first-line treatment option is widely prescribed for metastatic EC, however, its clinical application is extremely restricted by the low conversion rate to SN38, severe myelosuppression and diarrhea. As a more potent active metabolite of irinotecan, SN38 is a better substitution for irinotecan, but the poor water solubility and the difficulty of encapsulation hindered its medical application. Herein, a multifunctional SN38-conjugated nanosystem (FA-PDA@PZM/SN38@BSA-MnO2, denoted as FA-PPSM) is designed for overcoming the above-mentioned drawbacks and achieving collaborative chemotherapy, photodynamic therapy (PDT) and photothermal therapy (PTT). The tumor acidic microenvironment induces decomposition of BSA-MnO2 nanoparticles into O2 and Mn2+, thus enhancing oxygen-dependent PDT efficacy; meanwhile, Mn2+ can be employed as a magnetic resonance imaging (MRI) contrast agent. Under 650 and 808 nm laser irradiation, the FA-PPSM nanocomposites exhibit superior antitumor efficacy in Eca-109-tumor bearing mice. Notably, there is low gastrointestinal toxicity and myelosuppression in the FA-PPSM treated mice compared with those treated with irinotecan (alone). Taken together, this work highlights the great potential of the FA-PPSM nanocomposites for MRI-guided chemotherapy in combination with endoscopic light therapy for esophageal cancer.
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基于结构的前药合理设计，使其能够与聚合物纳米颗粒递送平台相结合，从而增强抗肿瘤功效。
影响因子：
16.6
作者：
Wang, Hangxiang;Xie, Haiyang;Wu, Jiaping;Wei, Xuyong;Zhou, Lin;Xu, Xiao;Zheng, Shusen
通讯作者：
Zheng, Shusen
DOI：
10.1016/j.jconrel.2017.07.014
发表时间：
2017-09-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Yang X;Xue X;Luo Y;Lin TY;Zhang H;Lac D;Xiao K;He Y;Jia B;Lam KS;Li Y
通讯作者：
Li Y
影响因子：
29.4
作者：
Chen, Qian;Feng, Liangzhu;Liu, Zhuang
通讯作者：
Liu, Zhuang
DOI：
10.2504/kds.60.1_1
发表时间：
2006
期刊：
The Journal of The Kyushu Dental Society
影响因子：
--
作者：
T. Inokuchi
通讯作者：
T. Inokuchi
影响因子：
19
作者：
Chen, Zhao-Xia;Liu, Miao-Deng;Zhang, Xian-Zheng
通讯作者：
Zhang, Xian-Zheng