Sub-100nm, long tumor retention SN-38-loaded photonic micelles for tri-modal cancer therapy.
Sub-100nm, long tumor retention SN-38-loaded photonic micelles for tri-modal cancer therapy.
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DOI：
10.1016/j.jconrel.2017.07.014
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发表时间：
2017-09-10
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Yang X;Xue X;Luo Y;Lin TY;Zhang H;Lac D;Xiao K;He Y;Jia B;Lam KS;Li Y
基于纳米颗粒的药物递送系统的肿瘤渗透和积累高度依赖于颗粒尺寸。先前的研究表明，亚100纳米范围内的纳米药物对各种实体瘤具有优异的抗肿瘤功效。 SN-38 是一种非常重要且高效的药物，可治疗包括结肠癌在内的多种癌症。然而，由于 SN-38 的超扁平芳香结构，在不改变化学结构的情况下，通常很难生产亚 100 nm 的 SN-38 封装的纳米颗粒。在这里，我们报告了成功生产 20-30 nm、SN-38 封装的光子胶束，用于有效的三模式癌症治疗。利用SN-38与一类独特的光子纳米卟啉胶束（NPM）之间的超分子“π-π”堆积和疏水性相互作用，将极其疏水的SN-38成功封装到NPM中，并显着提高了水溶性（高达500倍）。在同等剂量的药物光敏剂和光照射下，SN-38封装的纳米卟啉胶束（SN-NPM）联合治疗的体外抗肿瘤活性比单独使用SN-38和光疗分别提高了78和350倍。近红外荧光（NIRF）成像显示，由于尺寸相对较小，SN-NPM具有较长的肿瘤保留时间（> 5天）以及在肿瘤中比在正常器官中更高的积累。此外，与单一治疗相比，SN-NPM 的三模式疗法（光热疗法、光动力疗法和化疗）对携带 HT-29 结肠癌异种移植物的裸鼠的体内抗肿瘤功效显着增强。因此，这些亚 100 nm、SN-38 封装的光子胶束在多模式癌症治疗中显示出巨大的前景。
The tumor penetration and accumulation of nanoparticle-based drug delivery systems are highly dependent on the particle size. Nanomedicines in the sub-100 nm range have been suggested by previous studies to have superior antitumor efficacy on various solid tumors. SN-38 is a very important and highly potent drug for several cancers including colon cancer. However, due to the ultra-flat aromatic structure of SN-38, it is typically very difficult to produce sub-100 nm, SN-38-encapsulated nanoparticles without modification of the chemical structure. Here, we report on the successful production of 20–30 nm, SN-38-encapsulated photonic micelles for effectively trimodal cancer therapy. Taking advantages of the supramolecular “π -π” stacking and hydrophobicity interaction between SN-38, and a unique class of photonic nanoporphyrin micelles (NPM), the extremely hydrophobic SN-38 was successfully encapsulated into NPM with significantly increased water solubility (up to 500 times). At equivalent dose of drug photosensitizer and light irradiation, combination therapy with SN-38-encapsulated nanoporphyrin micelles (SN-NPM) enhanced the in vitro antitumor activity by 78 and 350 times over single treatment with SN-38 and phototherapy alone, respectively. Due to the relatively small size, SN-NPM possessed superior long tumor retention time (> 5 days) and much higher accumulation in tumors than in normal organs, as shown by near-infrared fluorescence (NIRF) imaging. Furthermore, the trimodal therapy (photothermal-, photodynamic- and chemo-therapy) with SN-NPM demonstrated dramatically enhanced in vivo antitumor efficacy over single treatment on nude mice bearing HT-29 colon cancer xenograft. Therefore, these sub-100 nm, SN-38-encapsulated photonic micelles show great promise for multimodal cancer therapy.
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影响因子：
17.1
作者：
Jang, Boseung;Park, Jin-Young;Choi, Yongdoo
通讯作者：
Choi, Yongdoo
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
DOI：
10.1016/j.jphotobiol.2013.08.001
发表时间：
2013-11-05
影响因子：
5.4
作者：
Hwang, Heejun;Biswas, Raktim;Ahn, Jin-Chul
通讯作者：
Ahn, Jin-Chul
影响因子：
2.4
作者：
Kah, James Chen Yong;Wan, Rachel Cheng Yi;Olivo, Malini
通讯作者：
Olivo, Malini
影响因子：
14
作者：
Li, WenTing;Peng, JinRong;Qian, ZhiYong
通讯作者：
Qian, ZhiYong