Incarceration exposure and epigenetic aging in neighborhood context.
Incarceration exposure and epigenetic aging in neighborhood context.
复制标题
社区背景下的监禁暴露和表观遗传老化。
DOI：
10.1016/j.socscimed.2022.115273
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Simons,RonaldL
中科院分区：
文献类型：
--
作者：
Berg,MarkT;Rogers,EthanM;Riley,Kendall;Lei,Man-Kit;Simons,RonaldL
研究表明，监禁暴露是健康的一个社会决定因素，最近的研究表明，监禁可能会引发压力反应，加速生理恶化。目前的研究的目的是评估是否邻里压力加剧的健康后果的监禁exposure.MethodsWe测试是否两个邻里环境措施-社会经济劣势和感知犯罪-温和的监禁暴露和衡量加速表观遗传衰老的基础上的GrimAge指数之间的关联。我们的样本包括408名非洲裔美国年轻人从家庭和社区健康study. ResultsFrom回归分析与治疗权重的逆概率的结果表明，监禁暴露和邻里劣势是独立与加速生物老化。结果还表明，监禁暴露对加速老化的影响被放大的个人在社区具有较高水平的感知criminal.ConclusionsThese研究结果表明，以前被监禁的个人返回的邻里环境有很大的影响，他们的生物老化的步伐。旨在减少释放后环境压力的政策可能会促进以前被监禁的非洲裔美国成年人的健康老龄化。
ObjectiveResearch has implicated incarceration exposure as a social determinant of health, with recent work suggesting incarceration may trigger a stress response that accelerates physiological deterioration. The objective of the current study is to assess whether neighborhood stressors intensify the health consequences of incarceration exposure.MethodsWe test whether two neighborhood context measures – socioeconomic disadvantage and perceived crime – moderate the association between incarceration exposure and a measure of accelerated epigenetic aging based on the GrimAge index. Our sample included 408 African American young adults from the Family and Community Health study.ResultsResults from regression analyses with inverse probability of treatment weights suggest that incarceration exposure and neighborhood disadvantage are independently associated with accelerated biological aging. The results also show that the impact of incarceration exposure on accelerated aging is amplified for individuals in neighborhoods with higher levels of perceived crime.ConclusionsThese findings indicate that the neighborhood contexts where formerly incarcerated individuals return have a substantial impact on their pace of biological aging. Policies aimed at reducing ambient stressors after release may promote healthy aging among formerly incarcerated African American adults.
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