Stress- and allostasis-induced brain plasticity.
Stress- and allostasis-induced brain plasticity.
复制标题
DOI：
10.1146/annurev-med-052209-100430
复制
发表时间：
2011
影响因子：
10.5
通讯作者：
Gianaros PJ
中科院分区：
文献类型：
--
作者：
McEwen BS;Gianaros PJ
大脑是应激过程的关键器官。它决定了个体会经历什么样的压力，它协调了个体如何科普压力体验，并且由于压力体验，它在功能和结构上都发生了变化。在大脑中，一个分布式的、动态的和可塑的神经回路协调、监测和校准行为和生理压力反应系统，以满足特定压力源的需求。这些别动力学过程在短期内可以是适应性的（别稳态），在长期内可以是适应不良的（别稳态负荷）。重要的是，这些过程涉及大脑和身体之间的双向信号。因此，非稳态和非稳态负荷可以共同影响大脑依赖性和压力相关的精神和身体健康状况的脆弱性。这篇综述着重于大脑可塑性的作用，在适应，病理生理造成的，压力的经验。它还考虑通过脑动力机制预防和治疗慢性和普遍健康状况的干预措施。
The brain is the key organ of stress processes. It determines what individuals will experience as stressful, it orchestrates how individuals will cope with stressful experiences, and it changes both functionally and structurally as a result of stressful experiences. Within the brain, a distributed, dynamic, and plastic neural circuitry coordinates, monitors, and calibrates behavioral and physiological stress response systems to meet the demands imposed by particular stressors. These allodynamic processes can be adaptive in the short term (allostasis) and maladaptive in the long term (allostatic load). Critically, these processes involve bidirectional signaling between the brain and body. Consequently, allostasis and allostatic load can jointly affect vulnerability to brain-dependent and stress-related mental and physical health conditions. This review focuses on the role of brain plasticity in adaptation to, and pathophysiology resulting from, stressful experiences. It also considers interventions to prevent and treat chronic and prevalent health conditions via allodynamic brain mechanisms.
登录
查看更多内容
影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
5.7
作者：
Ganzel, Barbara L.;Kim, Pilyoung;Temple, Elise
通讯作者：
Temple, Elise
影响因子：
34.7
作者：
DeRubeis, Robert J.;Siegle, Greg J.;Hollon, Steven D.
通讯作者：
Hollon, Steven D.
影响因子：
4.2
作者：
Hoelzel, Britta K.;Carmody, James;Lazar, Sara W.
通讯作者：
Lazar, Sara W.
影响因子：
4.2
作者：
Gianaros, Peter J;Horenstein, Jeffrey A;Cohen, Sheldon;Matthews, Karen A;Brown, Sarah M;Flory, Janine D;Critchley, Hugo D;Manuck, Stephen B;Hariri, Ahmad R
通讯作者：
Hariri, Ahmad R