A preliminary longitudinal magnetic resonance imaging study of brain volume and cortical thickness in autism.
A preliminary longitudinal magnetic resonance imaging study of brain volume and cortical thickness in autism.
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DOI：
10.1016/j.biopsych.2009.04.024
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发表时间：
2009-08-15
影响因子：
10.6
通讯作者：
Minshew, Nancy J.
中科院分区：
文献类型：
--
作者：
Hardan, Antonio Y.;Libove, Robin A.;Keshavan, Matcheri S.;Melhem, Nadine M.;Minshew, Nancy J.
Autism is a developmental neurobiologic disorder associated with structural and functional abnormalities in several brain regions including the cerebral cortex. This longitudinal study examines developmental changes in brain volume and cortical thickness (CT) using magnetic resonance imaging (MRI) in children with autism. MRI scans and behavioral measures were obtained at baseline and after a 30-month interval in a sample of males with autism (n=18) and healthy age-, and gender- matched controls (n=16) between the ages of 8 and 12 years at baseline. No differences in brain volumes were observed between the autism group and controls at baseline and at follow-up. However, differences in total grey matter volumes were observed over time with significantly greater decreases in the autism group compared to controls. Differences in CT were observed over time with greater decreases in the autism group compared to controls in several brain regions including the frontal lobe. Furthermore, several associations were observed between several clinical features and changes in CT with greater thinning of the cortex being correlated with more severe symptomatology. Findings from this study provide preliminary evidence for age-related changes in grey matter volume and CT in children with autism that are associated with symptoms severity. Future longitudinal studies of larger sample sizes are needed to evaluate developmental changes and examine the relationships between structural changes and clinical expressions of the disorder.
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影响因子：
14.5
作者：
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通讯作者：
Lantos, P
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Just, MA;Cherkassky, VL;Minshew, NJ
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Minshew, NJ
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