Key players in chromosome segregation in Caenorhabditis elegans.
Key players in chromosome segregation in Caenorhabditis elegans.
复制标题
DOI：
10.2741/3323
复制
发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Kitagawa R
中科院分区：
文献类型：
--
作者：
Kitagawa R
与许多真核生物中着丝粒组装在单着丝粒染色体的局部着丝粒上不同，秀丽隐杆线虫具有弥散的着丝粒，称为全着丝粒，其沿着有丝分裂染色体的整个长度组装。尽管这种细胞学上不同的染色体结构，C。线虫和其他真核生物的动粒在结构和功能上都具有保守的特性。姐妹着丝粒与微管的双端连接可以通过适当的染色体组织来实现，这依赖于保守蛋白质复合物的时空协调功能，例如C.中有丝分裂和减数分裂期间的粘着蛋白、凝聚蛋白和染色体乘客复合物。优雅的。此外，纺锤体组装检查点组件的结构及其保护功能在C.优美的近年来，人们对C. elegans纺锤体组装检查点揭示了其独特的功能。在这篇综述中，我将集中在蛋白质的保守性和多样性，需要保持染色体的有丝分裂和减数分裂过程中的染色体传递保真度。优雅的。
In contrast to many eukaryotic organisms in which kinetochores are assembled on localized centromeres of monocentric chromosomes, Caenorhabditis elegans has diffuse kinetochores, termed holo-kinetochores, which are assembled along the entire length of the mitotic chromosome. Despite this cytologically distinct chromosomal architecture, holo-kinetochores of C. elegans and kinetochores of other eukaryotes share structurally and functionally conserved properties. The amphitelic attachment of sister kinetochores to microtubules can be achieved by proper chromosomal organization, which relies on spatiotemporally orchestrated functions of conserved protein complexes such as the cohesin, condensin, and chromosomal passenger complexes during mitosis and meiosis in C. elegans. Moreover, the structure of spindle assembly checkpoint components and their safeguard function are also well conserved in C. elegans. Extensive efforts in the last few years to elucidate the molecular mechanisms of the C. elegans spindle assembly checkpoint have revealed its unique features. In this review, I will focus on the conservation and diversity of proteins that are required to maintain chromosome transmission fidelity during mitosis and meiosis in C. elegans.
登录
查看更多内容
影响因子：
1.6
作者：
ALBERTSON, DG;THOMSON, JN
通讯作者：
THOMSON, JN
影响因子：
2.6
作者：
Albertson, Donna G.;Thomson, J. Nichol
通讯作者：
Thomson, J. Nichol
影响因子：
10.5
作者：
CohenFix, O;Peters, JM;Koshland, D
通讯作者：
Koshland, D
影响因子：
64.5
作者：
Akhmanova, A;Hoogenraad, CC;Galjart, N
通讯作者：
Galjart, N
影响因子：
64.5
作者：
Ciosk, R;Zachariae, W;Nasmyth, K
通讯作者：
Nasmyth, K