Localization of secreted ferritin (FER2) in the embryos of the tick Haemaphysalis longicornis.

Localization of secreted ferritin (FER2) in the embryos of the tick Haemaphysalis longicornis.
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DOI:
10.1186/s13071-023-05669-5
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发表时间:
2023-01-30
影响因子:
3.2
通讯作者:
--
中科院分区:
医学2区
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尽管没有血粉,胚胎发生仍涉及许多需要营养和其他必需元素(包括铁)的过程。由于缺乏这些营养素的外部来源,这些需求是通过母体获得的。由于铁的毒性,它们通过铁转运分子(例如分泌性铁蛋白 (FER2))进行转移。在这里,我们试图通过间接免疫荧光追踪FER2的踪迹,我们观察到FER2从发育早期的胚层到胚胎发生后期的附属物发生了明显的转变。 FER2 也存在于胚胎腿的中部。这种明显的运动不仅揭示了胚胎发生过程中的铁加工事件,而且还间接指导了蜱的器官发生。在线版本包含可在 10.1186/s13071-023-05669-5 获取的补充材料。
Despite the absence of a blood meal, embryogenesis involves many processes that require nutrients and other essential elements, including iron. Due to the lack of an external source of these nutrients, these requirements are acquired maternally. Because of the toxic nature of iron, they are transferred through iron transport molecules such as secreted ferritin (FER2). Here we tried to follow the trail of the FER2 through indirect immunofluorescence, and we observed an apparent shift of FER2 from the germ layer at the early part of development to the appendages during the late stage of embryogenesis. FER2 is also found in the middle part of the legs of the embryo. The apparent movement not only sheds light on iron processing events during embryogenesis but also indirectly guides organogenesis in the tick. The online version contains supplementary material available at 10.1186/s13071-023-05669-5.
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