Retreatment of patients with chronic hepatitis C.
Retreatment of patients with chronic hepatitis C.
复制标题
慢性丙型肝炎患者的再治疗。
DOI：
10.1053/jhep.2002.36816
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Shiffman,MitchellL
中科院分区：
文献类型：
--
作者：
Shiffman,MitchellL
Significant advances have been made in the treatment of chronic hepatitis C virus (HCV) infection during the past 5 years. As a consequence, there is continuing enthusiasm for retreating patients who did not achieve sustained virological response (SVR) with previous therapy. Retreatment of non‐responders to standard interferon monotherapy using interferon and ribavirin has yielded SVR rates of 12% to 15%. Retreatment with peginterferon and ribavirin has been more effective; achieving SVR rates of 34% to 40%. Retreatment of patients who relapsed after interferon monotherapy using standard interferon and ribavirin yielded SVR rates of 47%, whereas retreatment with peginterferon and ribavirin resulted in an SVR rate of about 60%. The major factors associated with a higher likelihood of an SVR after retreatment include previous relapse, previous treatment with interferon monotherapy, HCV genotypes 2 or 3, lower serum levels of HCV RNA, and having a significant decrease in HCV RNA levels during the initial course of therapy. These results help to focus retreatment with peginterferon and ribavirin on subsets of patients who are most likely to benefit.
登录
查看更多内容
非人类灵长类动物的水凝胶角膜镜片术。
影响因子：
2
作者：
P. Binder;J. Deg;E. Zavala;K. Grossman
通讯作者：
K. Grossman
果蝇和人脑之间的单克隆抗体交叉反应。
DOI：
10.1073/pnas.80.24.7641
发表时间：
1983
影响因子：
11.1
作者：
C. Miller;S. Benzer
通讯作者：
S. Benzer
影响因子：
11.4
作者：
GOLDBERG, ML;PARO, R;GEHRING, WJ
通讯作者：
GEHRING, WJ
屈光性角膜移植术中角膜光学修饰的理论与计算
影响因子：
1.4
作者：
P. W. Churms
通讯作者：
P. W. Churms
DOI：
10.1085/jgp.79.3.361
发表时间：
1982-03
期刊：
The Journal of general physiology
影响因子：
--
作者：
Minke B
通讯作者：
Minke B