Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson's disease.
Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson's disease.
复制标题
帕金森氏病患者的丘脑下β带活性与运动障碍的长期相关性。
DOI：
10.1016/j.clinph.2017.08.028
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Kühn AA
中科院分区：
文献类型：
--
作者：
Neumann WJ;Staub-Bartelt F;Horn A;Schanda J;Schneider GH;Brown P;Kühn AA
研究丘脑底核β活性与帕金森病运动体征的长期相关性。我们招募了15名接受丘脑底DBS的帕金森病患者，在电极植入后以及术后3个月和8个月使用植入式传感启用Activa PC + S（Medtronic）进行局部场电位记录。3名患者退出，剩下12名患者。在休息时开启和关闭左旋多巴进行记录。提取β（13-35 Hz）峰值振幅，在不同时间点进行比较，并将其与EURS-III半身评分相关。在关闭药物状态下，在所有半球中发现β频带（13-35 Hz）中的峰。在所有记录的时间点，左旋多巴显著抑制了平均β活性（P < 0.007），并且在不同时间点和多巴胺能状态下，个体β功率振幅与帕金森病运动障碍相关（汇总数据; ρ = 0.25，P < 0.001）。我们的研究结果表明，β-活性与帕金森运动症状在8个月的时间内。β活性可能是PD症状严重程度的慢性可检测生物标志物，应在持续DBS下进一步评估。
To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. We recruited 15 patients with Parkinson’s disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8 months post-operatively using the implantable sensing enabled Activa PC + S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest. Beta (13–35 Hz) peak amplitudes were extracted, compared across time points and correlated with UPDRS-III hemibody scores. Peaks in the beta frequency band (13–35 Hz) in the OFF medication state were found in all hemispheres. Mean beta activity was significantly suppressed by levodopa at all recorded time points (P < 0.007) and individual beta power amplitude correlated with parkinsonian motor impairment across time points and dopaminergic states (pooled data; ρ = 0.25, P < 0.001). Our results indicate that beta-activity is correlated with parkinsonian motor signs over a time period of 8 months. Beta-activity may be a chronically detectable biomarker of symptom severity in PD that should be further evaluated under ongoing DBS.
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影响因子：
3.5
作者：
Jakab, A.;Blanc, R.;Szekely, G.
通讯作者：
Szekely, G.
影响因子：
8.6
作者：
Neumann, Wolf-Julian;Degen, Katharina;Schneider, Gerd-Helge;Bruecke, Christof;Huebl, Julius;Brown, Peter;Kuehn, Andrea A.
通讯作者：
Kuehn, Andrea A.
晚期帕金森病的自适应深脑刺激。
影响因子：
11.2
作者：
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
DOI：
10.1111/ner.12348
发表时间：
2016-01
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Neumann WJ;Staub F;Horn A;Schanda J;Mueller J;Schneider GH;Brown P;Kühn AA
通讯作者：
Kühn AA
影响因子：
3.4
作者：
Kühn, AA;Kupsch, A;Brown, P
通讯作者：
Brown, P