Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants.
Volume of white matter hyperintensities in healthy adults: contribution of age, vascular risk factors, and inflammation-related genetic variants.
复制标题
DOI：
10.1016/j.bbadis.2011.08.007
复制
发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Land S
中科院分区：
文献类型：
--
作者：
Raz N;Yang Y;Dahle CL;Land S
衰老与MRI扫描上出现白色高信号（WMH）有关。随着年龄的增长，血管风险和炎症增加，可能导致WMH的白色物质恶化和增殖。我们研究了与血管风险升高和炎症相关的循环生物标志物和遗传变异是否与健康成人（144名志愿者，44-77岁）的WMH体积相关。我们研究了WMH体积与年龄、性别、高血压、血浆总同型半胱氨酸（tHcy）、胆固醇（TC）（低密度脂蛋白）和C-反应蛋白（CRP），以及与血管风险和炎症相关的四种多态性：载脂蛋白ε（ApoE ε 2，3，4），血管紧张素转换酶插入/缺失（ACE I/D），亚甲基四氢叶酸还原酶（MTHFR）C677 T，C-反应蛋白（CRP）-286 C>A>T，白细胞介素-1 β（IL-1β）C-511 T。我们发现WMH体积较大与高龄、高血压以及同型半胱氨酸和CRP水平升高有关，但与低密度脂蛋白水平无关。IL-1β -511T等位基因纯合子和CRP-286 T等位基因携带者与炎症反应增加相关，其WMH大于其他等位基因组合。ε2等位基因携带者的额叶WMH大于ε3纯合子和ε4等位基因携带者。因此，在没有神经和血管疾病的健康成年人中，促进炎症和血管风险生物标志物水平升高的遗传变异可能导致大脑异常。
Aging is associated with appearance of white matter hyperintensities (WMH) on MRI scans. Vascular risk and inflammation, which increase with age, may contribute to white matter deterioration and proliferation of WMH. We investigated whether circulating biomarkers and genetic variants associated with elevated vascular risk and inflammation are associated with WMH volume in healthy adults (144 volunteers, 44-77 years of age). We examined association of WMH volume with age, sex, hypertension, circulating levels of total plasma homocysteine (tHcy), cholesterol (low-density lipoprotein), and C-reactive protein (CRP), and four polymorphisms related to vascular risk and inflammation: Apolipoprotein ε (ApoE ε2,3,4), Angiotensin-Converting Enzyme insertion/deletion (ACE I/D), methylenetetrahydrofolate reductase (MTHFR) C677T, C-reactive protein (CRP) -286 C>A>T, and interleukin-1β (IL-1β) C-511T. We found that larger WMH volume was associated with advanced age, hypertension, and elevated levels of homocysteine and CRP but not with low-density lipoprotein levels. Homozygotes for IL-1β -511T allele and carriers of CRP -286T allele that are associated with increased inflammatory response had larger WMH than the other allelic combinations. Carriers of the APOE ε2 allele had larger frontal WMH than ε3 homozygotes and ε4 carriers did. Thus, in healthy adults, who are free of neurological and vascular disease, genetic variants that promote inflammation and elevated levels of vascular risk biomarkers can contribute to brain abnormalities.
登录
查看更多内容
影响因子：
4.5
作者：
Bartzokis, George;Lu, Po H.;Stewart, Stephanie B.;Oluwadara, Bolanle;Lucas, Andrew J.;Pantages, Joanna;Pratt, Erika;Sherin, Jonathan E.;Altshuler, Lori L.;Mintz, Jim;Gitlin, Michael J.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
通讯作者：
Nuechterlein, Keith H.
影响因子：
2.3
作者：
Brickman, Adam M.;Zahra, Amir;Muraskin, Jordan;Steffener, Jason;Holland, Christopher M.;Habeck, Christian;Borogovac, Ajna;Ramos, Marco A.;Brown, Truman R.;Asllani, Iris;Stern, Yaakov
通讯作者：
Stern, Yaakov
影响因子：
8.3
作者：
Fornage, Myriam;Chiang, Y. Aron;Longstreth, W. T., Jr.
通讯作者：
Longstreth, W. T., Jr.
影响因子：
11
作者：
Artero, S;Tiemeier, H;Ritchie, K
通讯作者：
Ritchie, K
影响因子：
2.9
作者：
Dziedzic, T;Slowik, A;Szczudlik, A
通讯作者：
Szczudlik, A