Event-related potentials in alcoholic men: P3 amplitude reflects family history but not alcohol consumption.

Event-related potentials in alcoholic men: P3 amplitude reflects family history but not alcohol consumption.
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酗酒男性的事件相关电位:P3 幅度反映家族史,但不反映饮酒量。

DOI:
10.1111/j.1530-0277.1991.tb00611.x
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发表时间:
1991
期刊:
Alcoholism, clinical and experimental research
影响因子:
--
通讯作者:
Mathalon,D
Mathalon,D
中科院分区:
--
文献类型:
--
作者:
Pfefferbaum,A;Ford,JM;White,PM;Mathalon,D

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我们记录了男性酗酒者和年龄匹配的男性对照(26-60岁)的多导联事件相关电位(ERPs),分别由需要按下按钮反应的听觉和视觉刺激以及不需要反应的惊人噪音引起。对眨眼反应的单试验分析表明,酗酒者受惊的频率较低,但幅度与对照组相当。相比之下,P3的单试验分析表明,酗酒者产生P3的频率与对照组一样高,但他们的个体P3更小。报告有酗酒问题家族史的酗酒者比报告有酗酒问题家族史的酗酒者有更大的惊闪振幅和更小的听觉和视觉p3。分层回归分析表明,家族史阳性酗酒者较小的p3与终生饮酒量无关。
Multilead event‐related potentials (ERPs), elicited by auditory and visual stimuli requiring a button press response and by a startling noise requiring no response, were recorded from male alcoholics and age‐matched male controls (26–60 years old). Single‐trial analyses of blink responses to the startling stimuli indicated that alcoholics startle less frequently but with equivalent amplitude as the controls. In contrast, single‐trial analyses of P3 indicated that alcoholics generate a P3 as often as controls, but that their individual P3s are smaller. Alcoholics who reported a positive family history of problem drinking had larger startle blink amplitudes and smaller auditory and visual P3s than did alcoholics who reported a negative family history. Hierarchical regression analysis was used to demonstrate that smaller P3s in family history positive alcoholics were independent of lifetime alcohol consumption.
慢性酗酒者的长期脑损伤:模板匹配记忆任务中的 N2-P3 认知潜力。
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发表时间: 1985
影响因子: 2.8
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影响因子: --
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