Regulation of Staphylococcal Enterotoxin-Induced Inflammation in Spleen Cells from Diabetic Mice by Polyphenols.
Regulation of Staphylococcal Enterotoxin-Induced Inflammation in Spleen Cells from Diabetic Mice by Polyphenols.
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DOI：
10.3390/microorganisms11041039
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发表时间：
2023-04-15
期刊：
影响因子：
4.5
通讯作者：
Masuda S
中科院分区：
文献类型：
--
作者：
Shimamura Y;Noaki R;Oura Y;Ichikawa K;Kan T;Masuda S
众所周知，糖尿病患者在鼻道和皮肤上发现金黄色葡萄球菌后，更容易受到感染。本研究评价了葡萄球菌肠毒素A(SEA)对糖尿病小鼠脾细胞免疫应答的影响，并观察了多酚、儿茶素和甲基莲心素对免疫应答相关炎症相关基因表达的影响。(−)-表没食子儿茶素没食子酸酯(EGCG)具有羟基，与SEA相互作用，而Nobiletin(具有甲基)不与SEA相互作用。糖尿病小鼠脾细胞暴露于SEA后，干扰素γ、细胞因子信号转导抑制因子1、信号转导和转录激活因子3、干扰素诱导的跨膜蛋白3、Janus激酶2和干扰素调节因子3的表达增强，提示SEA敏感性在糖尿病的发生发展中是可变的。EGCG和nobiletin都改变了SEA诱导的脾细胞炎症相关基因的表达，表明它们通过不同的机制抑制炎症。这些结果可能有助于更好地理解SEA在糖尿病发生过程中诱导的炎症反应，并建立用多酚控制这些影响的方法。
Patients with diabetes are known to be more susceptible to infections following the establishment of Staphylococcus aureus in their nasal passages and on their skin. The present study evaluated the effects of staphylococcal enterotoxin A (SEA) on the immune responses of spleen cells derived from diabetic mice, and examined the effects of polyphenols, catechins, and nobiletin on inflammation-related gene expression associated with the immune response. (−)-Epigallocatechin gallate (EGCG), possessing hydroxyl groups, interacted with SEA, whereas nobiletin, possessing methyl groups, did not interact with SEA. The exposure of spleen cells derived from diabetic mice to SEA enhanced the expression of interferon gamma, suppressor of cytokine signaling 1, signal transducer and activator of transcription 3, interferon-induced transmembrane protein 3, Janus kinase 2, and interferon regulatory factor 3, suggesting that SEA sensitivity is variable in the development of diabetes. Both EGCG and nobiletin changed the expression of genes related to SEA-induced inflammation in spleen cells, suggesting that they inhibit inflammation through different mechanisms. These results may lead to a better understanding of the SEA-induced inflammatory response during diabetogenesis, and the establishment of methods to control these effects with polyphenols.
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