Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases.
Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases.
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DOI：
10.3390/molecules22111915
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发表时间：
2017-11-13
期刊：
影响因子：
--
通讯作者：
Mukwevho E
中科院分区：
文献类型：
--
作者：
Ayeleso TB;Matumba MG;Mukwevho E
对天然产物作为慢性疾病替代疗法的需求日益增加，鼓励了对植物生物活性化合物药理重要性的研究。最近，人们对齐墩果酸（OA）在预防和治疗慢性病方面的治疗潜力产生了浓厚的兴趣。齐墩果酸是一种广泛存在于植物中的五环三萜，包括水果和蔬菜，其提取和分离采用不同的技术和色谱平台。一些研究已经证明OA对不同疾病及其症状的潜在治疗作用。此外，齐墩果酸还可以作为开发新型半合成三萜的框架，这对于寻找各种疾病的治疗方式至关重要。近年来，在设计和合成OA的化学衍生物，以提高其溶解度，生物利用度和效力方面取得了新的进展。其中一些衍生物在一些临床试验中也已成为治疗候选者。本文对齐墩果酸在不同植物来源及其合成衍生物中的生物学效应及其在体外和体内研究模型中的作用机制进行了总结和扩展。这一综述表明齐墩果酸及其衍生物是寻找慢性疾病治疗和管理替代疗法的重要候选者。
The increasing demand for natural products as an alternative therapy for chronic diseases has encouraged research into the pharmacological importance of bioactive compounds from plants. Recently, there has been a surge of interest in the therapeutic potential of oleanolic acid (OA) in the prevention and management of chronic diseases. Oleanolic acid is a pentacyclic triterpenoid widely found in plants, including fruits and vegetables with different techniques and chromatography platforms being employed in its extraction and isolation. Several studies have demonstrated the potential therapeutic effects of OA on different diseases and their symptoms. Furthermore, oleanolic acid also serves as a framework for the development of novel semi-synthetic triterpenoids that could prove vital in finding therapeutic modalities for various ailments. There are recent advances in the design and synthesis of chemical derivatives of OA to enhance its solubility, bioavailability and potency. Some of these derivatives have also been therapeutic candidates in a number of clinical trials. This review consolidates and expands on recent reports on the biological effects of oleanolic acid from different plant sources and its synthetic derivatives as well as their mechanisms of action in in vitro and in vivo study models. This review suggests that oleanolic acid and its derivatives are important candidates in the search for alternative therapy in the treatment and management of chronic diseases.
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影响因子：
0.7
作者：
Bachhav SS;Bhutada MS;Patil SP;Sharma KS;Patil SD
通讯作者：
Patil SD
DOI：
10.1056/nejmoa1306033
发表时间：
2013-12-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
de Zeeuw D;Akizawa T;Audhya P;Bakris GL;Chin M;Christ-Schmidt H;Goldsberry A;Houser M;Krauth M;Lambers Heerspink HJ;McMurray JJ;Meyer CJ;Parving HH;Remuzzi G;Toto RD;Vaziri ND;Wanner C;Wittes J;Wrolstad D;Chertow GM;BEACON Trial Investigators
通讯作者：
BEACON Trial Investigators
影响因子：
7.2
作者：
Gao, Dawei;Li, Qingwang;Han, Zengsheng
通讯作者：
Han, Zengsheng
影响因子：
2.7
作者：
Chen, J;Liu, J;Sun, HB
通讯作者：
Sun, HB
影响因子：
3
作者：
Ben Gara, Amel;Kolsi, Rihab Ben Abdallah;Belghith, Karima
通讯作者：
Belghith, Karima