Comparison of hemodynamics of intracranial aneurysms between MR fluid dynamics using 3D cine phase-contrast MRI and MR-based computational fluid dynamics.
Comparison of hemodynamics of intracranial aneurysms between MR fluid dynamics using 3D cine phase-contrast MRI and MR-based computational fluid dynamics.
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DOI：
10.1007/s00234-009-0634-4
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发表时间：
2010-10
期刊：
影响因子：
2.8
通讯作者：
Sakahara, Harumi
中科院分区：
文献类型：
--
作者：
Isoda, Haruo;Ohkura, Yasuhide;Kosugi, Takashi;Hirano, Masaya;Alley, Marcus T.;Bammer, Roland;Pelc, Norbert J.;Namba, Hiroki;Sakahara, Harumi
关键词：
血流动力学被认为在颅内动脉瘤的发生、生长和破裂中起着非常重要的作用。本研究的目的是比较1.5 T下使用3D电影PC磁共振成像（4D-Flow）的磁共振流体动力学（MRFD）和基于磁共振的计算流体动力学（CFD）的颅内动脉瘤血流动力学。采用1.5 T MR扫描仪对5例颅内动脉瘤行4D-Flow手术。三维TOF磁共振血管造影获取几何信息。采用基于有限元法的CFD仿真方法对动脉瘤内血流进行建模。我们使用MR血管造影数据作为血管模型，MR血流信息作为CFD的边界条件。利用MRFD和CFD获得了三维速度矢量场、三维流线、剪切速度图、壁面剪应力（WSS）分布图和振荡剪切指数（OSI）分布图，并进行了比较。通过回归分析，MRFD与CFD在三维速度矢量场上的相关性为中高，在动脉瘤WSS上的相关性为中低。MRFD和CFD的三维流线模式相似。在动脉瘤内螺旋流的顶部，观察到较小的旋转剪切速度和较高的OSI。在MRFD和CFD中剪切速度的模式和位置是相似的。MRFD得到的高振荡剪切指数位置与CFD得到的位置接近。颅内动脉瘤的MRFD与CFD具有较好的相关性。
Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to compare hemodynamics of intracranial aneurysms of MR fluid dynamics (MRFD) using 3D cine PC MR imaging (4D-Flow) at 1.5 T and MR-based computational fluid dynamics (CFD). 4D-Flow was performed for five intracranial aneurysms by a 1.5 T MR scanner. 3D TOF MR angiography was performed for geometric information. The blood flow in the aneurysms was modeled using CFD simulation based on the finite element method. We used MR angiographic data as the vascular models and MR flow information as boundary conditions in CFD. 3D velocity vector fields, 3D streamlines, shearing velocity maps, wall shear stress (WSS) distribution maps and oscillatory shear index (OSI) distribution maps were obtained by MRFD and CFD and were compared. There was a moderate to high degree of correlation in 3D velocity vector fields and a low to moderate degree of correlation in WSS of aneurysms between MRFD and CFD using regression analysis. The patterns of 3D streamlines were similar between MRFD and CFD. The small and rotating shearing velocities and higher OSI were observed at the top of the spiral flow in the aneurysms. The pattern and location of shearing velocity in MRFD and CFD were similar. The location of high oscillatory shear index obtained by MRFD was near to that obtained by CFD. MRFD and CFD of intracranial aneurysms correlated fairly well.
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影响因子：
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