Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria.
Structural diversity and biological significance of lipoteichoic acid in Gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria.
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脂肪酸在革兰氏阳性细菌中的结构多样性和生物学意义：专注于有益的益生菌乳酸菌。
DOI：
10.12938/bmfh.2016-006
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yokota A
中科院分区：
文献类型：
--
作者：
Shiraishi T;Yokota S;Fukiya S;Yokota A
细菌细胞表面分子处于宿主与细菌相互作用的最前沿。磷壁酸仅在革兰氏阳性细菌中观察到，它们是主要的细胞表面成分之一。磷壁酸发挥着重要的生理作用，有助于细菌与其宿主的相互作用。特别是，锚定在细胞膜上的脂磷壁酸（LTA）作为宿主免疫调节剂引起了人们的关注。不同细菌的 LTA 的化学和生物学特性已被描述。然而，大多数信息涉及致病菌，而有关有益菌（包括益生菌乳酸菌）的信息不足。 LTA 结构多样。 LTA 的菌株水平结构多样性被认为是其免疫调节活性的基础。因此，益生菌中 LTA 的结构信息，特别是菌株相关的多样性，对于理解其与免疫反应调节相关的有益作用非常重要。结构信息的持续积累对于阐明 LTA 的详细生理作用和意义是必要的。在这篇综述文章中，我们总结了 LTA 结构的知识现状，特别是乳酸菌的 LTA 结构。我们还描述了 LTA 结构多样性和生物学作用的重要性。
Bacterial cell surface molecules are at the forefront of host-bacterium interactions. Teichoic acids are observed only in Gram-positive bacteria, and they are one of the main cell surface components. Teichoic acids play important physiological roles and contribute to the bacterial interaction with their host. In particular, lipoteichoic acid (LTA) anchored to the cell membrane has attracted attention as a host immunomodulator. Chemical and biological characteristics of LTA from various bacteria have been described. However, most of the information concerns pathogenic bacteria, and information on beneficial bacteria, including probiotic lactic acid bacteria, is insufficient. LTA is structurally diverse. Strain-level structural diversity of LTA is suggested to underpin its immunomodulatory activities. Thus, the structural information on LTA in probiotics, in particular strain-associated diversity, is important for understanding its beneficial roles associated with the modulation of immune response. Continued accumulation of structural information is necessary to elucidate the detailed physiological roles and significance of LTA. In this review article, we summarize the current state of knowledge on LTA structure, in particular the structure of LTA from lactic acid bacteria. We also describe the significance of structural diversity and biological roles of LTA.
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影响因子：
6.7
作者：
Baur S;Rautenberg M;Faulstich M;Grau T;Severin Y;Unger C;Hoffmann WH;Rudel T;Autenrieth IB;Weidenmaier C
通讯作者：
Weidenmaier C
影响因子：
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作者：
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影响因子：
3.1
作者：
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通讯作者：
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