Nucleus reuniens transiently synchronizes memory networks at beta frequencies.
Nucleus reuniens transiently synchronizes memory networks at beta frequencies.
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DOI：
10.1038/s41467-023-40044-z
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发表时间：
2023-07-19
影响因子：
16.6
通讯作者：
Allen TA
中科院分区：
文献类型：
--
作者：
Jayachandran M;Viena TD;Garcia A;Veliz AV;Leyva S;Roldan V;Vertes RP;Allen TA
基于情景记忆的决策需要自上而下的内侧前额叶皮层和海马的相互作用。这种整合的前额叶-海马记忆状态被认为是由同步的网络振荡组织的，并由与丘脑连合核（RE）的连接介导。然而，RE是否以及如何影响记忆中的前额叶-海马网络仍然未知。在这里，我们记录了当地的场电位从额前RE海马网络，而大鼠从事非空间序列记忆任务，从而隔离记忆相关的活动，从运行相关的振荡。我们发现，在记忆试验期间，同步的额前海马β爆发（15-30 Hz）占主导地位，而在非记忆相关的跑步期间，同步的θ活动（6-12 Hz）占主导地位。此外，RE β活性首先出现，其次是前额和海马同步β，表明前额-海马β可能由RE驱动。为了测试RE是否能够驱动前额叶-海马β同步，我们使用了光遗传学方法（retroAAV-ChR 2）。RE激活诱导前额叶-海马β相干性和降低θ相干性，与序列任务中观察到的记忆驱动网络状态相匹配。这些发现首次证明RE通过在前额叶海马系统中驱动瞬时同步β来促进记忆，从而促进基于记忆的决策的相互作用。前额叶皮层与海马体相互作用以指导记忆，但驱动功能连接的机制尚不清楚。在这里，作者证明，核reuniens eleventually同步在β（15-30赫兹）的节奏在检索。
Episodic memory-based decision-making requires top-down medial prefrontal cortex and hippocampal interactions. This integrated prefrontal-hippocampal memory state is thought to be organized by synchronized network oscillations and mediated by connectivity with the thalamic nucleus reuniens (RE). Whether and how the RE synchronizes prefrontal-hippocampal networks in memory, however, remains unknown. Here, we recorded local field potentials from the prefrontal-RE-hippocampal network while rats engaged in a nonspatial sequence memory task, thereby isolating memory-related activity from running-related oscillations. We found that synchronous prefrontal-hippocampal beta bursts (15–30 Hz) dominated during memory trials, whereas synchronous theta activity (6–12 Hz) dominated during non-memory–related running. Moreover, RE beta activity appeared first, followed by prefrontal and hippocampal synchronized beta, suggesting that prefrontal-hippocampal beta could be driven by the RE. To test whether the RE is capable of driving prefrontal-hippocampal beta synchrony, we used an optogenetic approach (retroAAV-ChR2). RE activation induced prefrontal-hippocampal beta coherence and reduced theta coherence, matching the observed memory-driven network state in the sequence task. These findings are the first to demonstrate that the RE contributes to memory by driving transient synchronized beta in the prefrontal-hippocampal system, thereby facilitating interactions that underlie memory-based decision-making. The prefrontal cortex interacts with the hippocampus to guide memory, but the mechanisms driving functional connectivity are unknown. Here, the authors demonstrate that the nucleus reuniens elicits synchronizations at beta (15–30 Hz) rhythms during retrieval.
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影响因子：
8.2
作者：
Ferraris, Maeva;Cassel, Jean-Christophe;Quilichini, Pascale P.
通讯作者：
Quilichini, Pascale P.
影响因子：
5.3
作者：
Angulo-Garcia, David;Ferraris, Maeva;Quilichini, Pascale P.
通讯作者：
Quilichini, Pascale P.
DOI：
10.1523/jneurosci.4122-11.2012
发表时间：
2012-01-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Belluscio MA;Mizuseki K;Schmidt R;Kempter R;Buzsáki G
通讯作者：
Buzsáki G
前额叶皮层中第1层电路的丘脑控制。
DOI：
10.1523/jneurosci.3231-12.2012
发表时间：
2012-12-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cruikshank SJ;Ahmed OJ;Stevens TR;Patrick SL;Gonzalez AN;Elmaleh M;Connors BW
通讯作者：
Connors BW
影响因子：
3
作者：
Bokil, Hemant;Andrews, Peter;Kulkarni, Jayant E.;Mehta, Samar;Mitra, Partha P.
通讯作者：
Mitra, Partha P.