Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.

Experimental models of lymphoproliferative disease. The mouse as a model for human non-Hodgkin's lymphomas and related leukemias.
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淋巴组织增生性疾病的实验模型。

DOI:
--
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发表时间:
1983
影响因子:
6
通讯作者:
C. Taylor
C. Taylor
中科院分区:
医学2区
文献类型:
--
作者:
P. Pattengale;C. Taylor

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本综述着重于小鼠作为人类非霍奇金淋巴瘤和相关白血病的实验免疫病理模型。免疫形态学证据清楚地表明,B-和T-细胞亚型的小鼠(鼠)淋巴瘤/白血病密切相似,并类似于B-和T-细胞亚型的人淋巴瘤/白血病定义最近提出的免疫形态学分类。进一步的证据支持这样的假设:某些类型的小鼠和人类B细胞淋巴瘤是从前驱、淋巴瘤前状态发展而来的,表现出先前的形态和免疫异常。许多实验优势的小鼠系统的强调,以及目前定义的免疫形态学方法应有效地结合分子和细胞遗传学参数的概念。
The present review focuses on the mouse as an experimental immunopathologic model for human non-Hodgkin's lymphomas and related leukemias. Immunomorphologic evidence is presented that clearly demonstrates that B- and T-cell subtypes of mouse (murine) lymphoma/leukemia closely resemble and are analogous to B- and T-cell subtypes of human lymphoma/leukemia as defined by recently proposed immunomorphologic classifications. Further evidence is presented that favors the hypothesis that certain types of murine and human B-cell lymphoma develop out of prodromal, prelymphomatous states, which exhibit antecedent morphologic and immunologic abnormalities. The many experimental advantages of the murine systems are stressed, as well as the concept that the presently defined immunomorphologic approach should be effectively combined with molecular and cytogenetic parameters.
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发表时间: 1982-01-01
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影响因子: --
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DOI: --
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