Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012.
Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012.
复制标题
2012年中国沙沃肠道病毒71型感染及相关手足口病疫情特征
DOI：
10.1038/srep38451
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发表时间：
2016-12-12
影响因子：
4.6
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Liu MY;Liu J;Lai W;Luo J;Liu Y;Vu GP;Yang Z;Trang P;Li H;Wu J
肠病毒71型（EV71）感染和相关的手足口病（手足口病）被认为是世界范围内新出现的公共卫生问题。仅在中国，每年就有数十万儿童感染EV71并发展为手足口病。研究EV71感染对治疗和预防相关手足口病暴发至关重要。在本报告中，我们研究了2012年9月至10月在中国沙窝镇爆发的105例手足口病病例。超过90%的病例为9岁以下儿童，超过50%的病例年龄在3-6岁。实验室研究发现EV71型流行率很高，并提示EV71型是沙窝最常见的引起手足口病的肠道病毒。测序结果表明，沙窝EV71病毒属C4亚基因型，与南昌的亲缘关系较近，与武汉的亲缘关系较近，且变异明显。其中，沙沃女童较多，武汉和南昌男童较多。我们的研究进一步加深了对中国手足口病分子流行病学特征和肠道病毒感染的认识。
Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment and prevention of the associated HFMD outbreaks. In this report, we studied an outbreak of 105 HFMD cases in Shawo Township of China between September to October 2012. More than 90% of cases were children younger than 9 years old, with over 50% of cases aged 3–6 years old. Laboratory studies detected a high prevalence of EV71 and suggested EV71 as the most common enterovirus causing HFMD in Shawo. Sequencing analysis showed that the EV71 strains from Shawo belong to the C4 subgenotype, and are phylogenetically more related to those from the distant city of Nanchang than those from the nearby city of Wuhan with distinct variations. More girls were found to be associated with EV71 in Shawo whereas more boys were associated with EV71 in Wuhan and Nanchang. Our studies further the understanding of the molecular epidemiological features of HFMD and infection by enteroviruses in China.
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