Characterization of an outbreak of hand, foot, and mouth disease in Nanchang, China in 2010.
Characterization of an outbreak of hand, foot, and mouth disease in Nanchang, China in 2010.
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2010年，中国南昌的手，脚和口腔疾病的爆发表征。
DOI：
10.1371/journal.pone.0025287
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Liu MY;Liu W;Luo J;Liu Y;Zhu Y;Berman H;Wu J
中国最近暴发的人类肠道病毒71型（EV71）感染和与EV71相关的手足口病（HFMD）已影响数百万人，并可能导致危及生命的新生儿并发症。此外，这些暴发是世界上一个重大的全球公共卫生问题。了解中国手足口病和EV71感染的流行病学及其传播模式对控制疫情至关重要。然而，2010年中国没有关于手足口病和EV71型感染暴发的研究报告。在本报告中，我们对2010年在中华人民共和国江西省南昌市暴发的手足口病和EV71感染进行了流行病学分析。2010年4月7日至5月11日，共报告手足口病病例109例，对病例进行流行病学和实验室分析。流行病学研究表明，8岁以下儿童占报告病例的90%以上，其中1-3岁年龄组的病例数最多。实验室检测结果显示，本研究病例中EV71的流行率较高，提示EV71是南昌市手足口病病例中常见的肠道病毒。4株EV71分离株VP1区序列的系统发育分析表明，南昌株属于2008年疫情中常见的C4亚基因型，但与这些菌株存在明显差异。本研究首次揭示了2010年中国手足口病和EV71感染的流行病学特征，并首次提供了中国南昌市流行EV71基因型的直接证据。本研究可为中国手足口病和EV71型感染的公共卫生控制和预防措施的制定提供参考。
Recent outbreaks of human enterovirus 71 (EV71) infection and EV71-associated hand, foot, and mouth disease (HFMD) in China have affected millions and potentially lead to life-threatening complications in newborns. Furthermore, these outbreaks represent a significant global public health issue in the world. Understanding the epidemiology of HFMD and EV71 infection and their transmission patterns in China is essential for controlling outbreaks. However, no studies on the outbreaks of HFMD and EV71 infection in China during 2010 have been reported. In this report, we carried out an epidemiological analysis to study an outbreak of HFMD and EV71 infection in 2010 in the city of Nanchang in the Jiangxi province of People's Republic of China. From April 7 to May 11, 2010, a total of 109 HFMD cases were reported, and in this report the HFMD cases were studied by both epidemiological and laboratory analyses. The epidemiological study indicates that children aged younger than 8 years old represented more than 90% of the reported cases, with the age group of 1–3 years containing the highest number of cases. Laboratory studies detected a high prevalence of EV71 amongst the cases in our study, suggesting EV71 as a common enterovirus found in HFMD cases in Nanchang. Phylogenetic analysis of the sequence of the VP1 region of four EV71 isolates indicated that the Nanchang strains belong to the C4 subgenotype commonly found in China during outbreaks in 2008 but contain distinct variations from these strains. Our study for the first time characterizes the epidemiology of HFMD and EV71 infection in China in 2010 and furthermore, provides the first direct evidence of the genotype of EV71 circulating in Nanchang, China. Our study should facilitate the development of public health measures for the control and prevention of HFMD and EV71 infection in at-risk individuals in China.
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