Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization
Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization
复制标题
趋化因子样因子1通过诱导肌动蛋白聚合促进大鼠原代皮质神经元的迁移
DOI：
10.1097/wnr.0000000000000252
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发表时间：
2014-10
期刊：
影响因子：
1.7
通讯作者：
Chen Nai-Hong
中科院分区：
文献类型：
--
作者：
Wang Xiao-Feng;Chu Shi-Feng;Han Ning;Chen Nai-Hong
趋化因子样因子1（CKLF1）是一种新克隆的趋化因子，在免疫细胞迁移中起重要作用。然而，CKLF1在皮质神经元迁移中的潜在作用仍不清楚。在本研究中，通过测量脑切片的边缘和迁移细胞的领先群体之间的距离，我们发现，细胞迁移的程度显着增强CKLF1治疗，这是显着抑制同时加入抗CKLF1抗体。通过免疫荧光染色，发现CKLF 1诱导原代大脑皮层神经元肌动蛋白聚合。通过创伤愈合实验，发现CKLF 1以剂量依赖性方式刺激皮层神经元的迁移。总之，我们的数据表明，CKLF1促进迁移的大鼠原代大脑皮层神经元的诱导肌动蛋白聚合。
Chemokine-like factor 1 (CKLF1), a newly cloned chemotactic cytokine, plays an essential role in immune cell migration. However, the potential role of CKLF1 in the cortical neuronal migration remains unclear. In the present research, by measuring the distance between the margin of brain slices and the leading population of migrating cells, we showed that the extent of cell migration was markedly enhanced in response to CKLF1 treatment, which was significantly inhibited by the simultaneous addition of anti-CKLF1 antibody. By immunofluorescence staining, it was found that CKLF1 induced actin polymerization in primary cerebral cortical neurons. By wound-healing assays, it was found that CKLF1 stimulated the migration of cortical neurons in a dose-dependent manner. In conclusion, our data suggest that CKLF1 promotes the migration of rat primary cerebral cortical neurons by the induction of actin polymerization.
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影响因子：
4.1
作者：
Han, WL;Lou, YX;Ma, DL
通讯作者：
Ma, DL
影响因子：
3.8
作者：
Matsuo N;Shiraha H;Fujikawa T;Takaoka N;Ueda N;Tanaka S;Nishina S;Nakanishi Y;Uemura M;Takaki A;Nakamura S;Kobayashi Y;Nouso K;Yagi T;Yamamoto K
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Yamamoto K
影响因子：
3.5
作者：
W. Rostène;J. Buckingham
通讯作者：
W. Rostène;J. Buckingham
DOI：
10.1677/joe.0.1650123
发表时间：
2000-04
期刊：
The Journal of endocrinology
影响因子：
--
作者：
A. Puglianiello;D. Germani;P. Rossi;S. Cianfarani
通讯作者：
A. Puglianiello;D. Germani;P. Rossi;S. Cianfarani
影响因子：
2.5
作者：
Zhen-Zhen Wang-Zhen;Yi Zhang;Yu-he Yuan;N. Chen
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Zhen-Zhen Wang-Zhen;Yi Zhang;Yu-he Yuan;N. Chen