Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: Forty-Eight-Month Follow-Up Data From the Osteoarthritis Initiative.
Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: Forty-Eight-Month Follow-Up Data From the Osteoarthritis Initiative.
复制标题
DOI：
10.1002/acr.24554
复制
发表时间：
2022-07
影响因子：
4.7
通讯作者：
Segal NA
中科院分区：
文献类型：
--
作者：
Hu B;Han D;Nevitt MC;Wise BL;Segal NA
确定体力活动量（PA）是否是膝关节骨关节炎（OA）受试者48个月内关节间隙狭窄（JSN）恶化的决定因素。数据来自骨关节炎倡议。使用老年人体力活动量表（PASE）测量的PA定义为在JSN恶化之前进行的年度测量的平均值。JSN恶化定义为与基线相比，48个月内OARSI JSN评分至少部分等级增加。基于PA和JSN恶化之间的线性关联，使用限制性三次样条（RCS）函数对参与者进行分组。使用合并逻辑回归模型来评估PA和JSN恶化之间的相关性，调整混杂因素。2,167名参与者参加了会议。总共有625名（28.8%）参与者在48个月内JSN恶化。与PASE评分140-180相比，PASE评分100-140和>220与男性JSN恶化风险增加相关，OR（95%CI）分别为1.73（1.07，2.81）和1.83（1.14，2.93）。同样，在Kellgren和Lawrence分级为2级的受试者中，与PASE评分为140-180相比，PASE评分为<100 and >220与JSN恶化风险增加相关，OR（95%CI）分别为1.69（1.13，2.54）和1.64（1.05，2.56）。与中度PA相比，较高或较低量的PA与男性和KL 2级膝关节受试者的JSN恶化风险升高相关。
To determine whether amount of physical activity (PA) is a determinant of joint space narrowing (JSN) worsening over 48-months in participants with knee osteoarthritis (OA). Data were obtained from the Osteoarthritis Initiative. PA, measured using the Physical Activity Scale for the Elderly (PASE), was defined as the mean value of the annual measurements conducted prior to development of worsening JSN. Worsening JSN was defined as at least a partial grade increase in OARSI JSN score over 48 months, in comparison with baseline. Restricted cubic spline (RCS) function was used to group participants based on the linear association between PA and JSN worsening. A pooled logistic regression model was used to evaluate the association between PA and JSN worsening adjusted for confounders. 2,167 participants were included. In total, 625 (28.8%) participants had JSN worsening over 48 months. Compared with PASE score of 140–180, PASE scores of 100–140 and >220 associated with an increased risk of JSN worsening in men with OR (95% CI) of 1.73 (1.07, 2.81) and 1.83 (1.14, 2.93) respectively. Similarly, in participants with Kellgren and Lawrence grade 2, compared with a PASE score of 140–180, PASE score of <100 and >220 were associated with increased risks of JSN worsening, with OR (95% CIs) of 1.69 (1.13, 2.54) and 1.64 (1.05, 2.56) respectively. Compared to moderate PA, higher or lower amounts of PA are associated with elevated risk for JSN worsening in men and in participants with KL grade 2 knees.
登录
查看更多内容
影响因子：
7
作者：
Felson, D. T.;Niu, J.;Nevitt, M. C.
通讯作者：
Nevitt, M. C.
影响因子：
9.8
作者：
Lephart, SM;Pincivero, DM;Rozzi, SL
通讯作者：
Rozzi, SL
影响因子：
3.4
作者：
Calling, Susanna;Hedblad, Bo;Janzon, Lars
通讯作者：
Janzon, Lars
影响因子：
7
作者：
Baliunas, AJ;Hurwitz, DE;Andriacchi, TP
通讯作者：
Andriacchi, TP
影响因子：
7
作者：
Lin, W.;Alizai, H.;Link, T. M.
通讯作者：
Link, T. M.