Burden of Gastric Cancer.
Burden of Gastric Cancer.
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DOI：
10.1016/j.cgh.2019.07.045
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发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
El-Serag HB
中科院分区：
文献类型：
--
作者：
Thrift AP;El-Serag HB
胃癌是一个全球性的健康问题，全球每年有100多万人被诊断为胃癌。尽管在过去的50年里，胃癌的发病率和死亡率在全球范围内有所下降，但它仍然是癌症相关死亡的第三大原因。对全球和地区的胃癌流行病学和风险因素的了解对于执业胃肠病医生做出关于风险分层、筛查和预防的个性化决策是至关重要的。在这篇文章中，我们回顾了胃癌的流行病学以及减少全球胃癌发病率和死亡率的筛查和预防努力。首先，我们讨论了胃癌的描述流行病学，包括其发病率、死亡率、存活率和长期趋势。我们结合已发表的研究综述和对国际癌症研究机构(IARC)GLOBOCAN项目的数据分析来描述全球胃癌负担，以及来自美国癌症统计(USCS)登记的数据来讨论美国胃癌发病率的变化。接下来，我们总结当前关于胃癌危险因素的知识。最后，我们讨论了胃癌的预防策略和筛查工作。
Gastric cancer is a global health problem, with more than 1 million people newly diagnosed with gastric cancer worldwide each year. Despite its worldwide decline in incidence and mortality over the past five decades, gastric cancer remains the third leading cause of cancer-related death. Knowledge of global as well as regional epidemiology and risk factors for gastric cancer is essential for the practicing gastroenterologist to make personalized decisions about risk stratification, screening and prevention. In this article, we review the epidemiology of gastric cancer as well as screening and prevention efforts to reduce global morbidity and mortality from gastric cancer. First, we discuss the descriptive epidemiology of gastric cancer, including its incidence, mortality, survival, and secular trends. We combine a synthesis of published studies with an analysis of data from the International Agency for Research on Cancer (IARC) GLOBOCAN project to describe the global burden of gastric cancer and data from the United States Cancer Statistics (USCS) registry to discuss the change in incidence of gastric cancer in the U.S. Next, we summarize current knowledge of risk factors for gastric cancer. Finally, we discuss prevention strategies and screening efforts for gastric cancer.
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