Exploring the relationship between maternal prenatal stress and brain structure in premature neonates.
Exploring the relationship between maternal prenatal stress and brain structure in premature neonates.
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DOI：
10.1371/journal.pone.0250413
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Victor S
中科院分区：
文献类型：
--
作者：
Lautarescu A;Hadaya L;Craig MC;Makropoulos A;Batalle D;Nosarti C;Edwards AD;Counsell SJ;Victor S
在子宫内暴露于母体压力与一系列不良后果有关。我们之前在早产婴儿样本中观察到母亲压力和白质微观结构之间的关联。本研究旨在探讨母亲特质焦虑、应激性生活事件与脑容量的关系。221例早产婴儿（114男，107女）（中位胎龄30.43周[范围23.57-32.86]）在足月等效年龄（平均42.20周，SD = 1.60）前后接受了磁共振成像。提取以下感兴趣区域的脑容量：额叶、颞叶、杏仁核、海马、丘脑，并将其归一化为总脑容量。在控制出生胎龄、经后扫描年龄、社会经济地位、性别、总肠外营养天数的情况下，采用多元线性回归研究产妇焦虑/压力与脑容量之间的关系。额外的探索性的基于张量的形态测量分析被执行，以获得雅可比行列式图的体素脑容量变化。在这项大型前瞻性研究中，我们没有发现母亲产前压力或特质焦虑与脑容量之间关系的证据。对于使用兴趣区域方法的主要分析和使用雅可比行列式映射的探索性分析都是如此。我们在先前研究中相互矛盾的证据的背景下讨论这些结果，并强调需要进一步研究早产儿，特别是包括足月出生的对照组。
Exposure to maternal stress in utero is associated with a range of adverse outcomes. We previously observed an association between maternal stress and white matter microstructure in a sample of infants born prematurely. In this study, we aimed to investigate the relationship between maternal trait anxiety, stressful life events and brain volumes. 221 infants (114 males, 107 females) born prematurely (median gestational age = 30.43 weeks [range 23.57–32.86]) underwent magnetic resonance imaging around term-equivalent age (mean = 42.20 weeks, SD = 1.60). Brain volumes were extracted for the following regions of interest: frontal lobe, temporal lobe, amygdala, hippocampus, thalamus and normalized to total brain volume. Multiple linear regressions were conducted to investigate the relationship between maternal anxiety/stress and brain volumes, controlling for gestational age at birth, postmenstrual age at scan, socioeconomic status, sex, days on total parenteral nutrition. Additional exploratory Tensor Based Morphometry analyses were performed to obtain voxel-wise brain volume changes from Jacobian determinant maps. In this large prospective study, we did not find evidence of a relationship between maternal prenatal stress or trait anxiety and brain volumes. This was the case for both the main analysis using a region-of-interest approach, and for the exploratory analysis using Jacobian determinant maps. We discuss these results in the context of conflicting evidence from previous studies and highlight the need for further research on premature infants, particularly including term-born controls.
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DOI：
10.3109/10253890.2011.623250
发表时间：
2011-11
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Buss C;Davis EP;Hobel CJ;Sandman CA
通讯作者：
Sandman CA
影响因子：
5.8
作者：
Almond, Palo
通讯作者：
Almond, Palo
影响因子：
7.4
作者：
El Marroun, Hanan;Tiemeier, Henning;White, Tonya J. H.
通讯作者：
White, Tonya J. H.
影响因子：
4.8
作者：
Allen, Marilee C.
通讯作者：
Allen, Marilee C.
影响因子：
26.1
作者：
Dean DC 3rd;Planalp EM;Wooten W;Kecskemeti SR;Adluru N;Schmidt CK;Frye C;Birn RM;Burghy CA;Schmidt NL;Styner MA;Short SJ;Kalin NH;Goldsmith HH;Alexander AL;Davidson RJ
通讯作者：
Davidson RJ