No significant independent relationships with cardiometabolic biomarkers were detected in the Observation of Cardiovascular Risk Factors in Luxembourg study population.
No significant independent relationships with cardiometabolic biomarkers were detected in the Observation of Cardiovascular Risk Factors in Luxembourg study population.
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DOI：
10.1016/j.nutres.2014.07.017
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Hébert JR
中科院分区：
文献类型：
--
作者：
Alkerwi A;Shivappa N;Crichton G;Hébert JR
最近，人们对饮食在慢性和代谢性疾病中的抗炎作用产生了浓厚的研究兴趣。一种基于文献的饮食炎症指数（DII）可以用来表征个体饮食的炎症调节能力，甚至已经在美国人群中得到了发展和验证。我们假设DII可以预测高敏c反应蛋白（CRP）水平，这是一个重要的炎症标志物，以及代谢指标，包括欧洲成年人的代谢综合征及其组成部分。这一假设是根据1352名参与者的数据进行检验的，这些数据来自卢森堡心血管风险因素观察研究，这是一项基于卢森堡的全国性横断面调查。统计方法包括描述性和多变量logistic回归分析。DII的范围从最小的- 4.02（最抗炎）到最大的4.00点，平均值为- 0.41。DII评分较高的参与者明显更年轻，身体质量指数、腰围和收缩压水平都较低。其他心血管生物标志物包括舒张压、CRP、脂质和血糖生物标志物在DII三分之一组中没有显著差异。与具有抗炎评分（DII≤1）的受试者相比，具有促炎（bbb1） DII评分的受试者具有较低的高密度脂蛋白胆固醇的校正优势（优势比为1.46；95%可信区间为1.00-2.13）。高敏CRP与DII之间无明显关系。这项研究测试了美国以外的DII的炎症能力，通过使用食物频率问卷收集的数据，没有发现与心脏代谢生物标志物之间存在显著的独立关系。这些结果提供了信息，并代表了指导未来营养和饮食质量研究的相关步骤。
Recently, there has been an influx of research interest regarding the anti-inflammatory role that diet has in chronic and metabolic diseases. A literature-based dietary inflammatory index (DII) that can be used to characterize the inflammation-modulating capacity of individuals’ diets has even been developed and validated in an American population. We hypothesized that the DII could predict levels of high-sensitivity C-reactive protein (CRP), which is an important inflammatory marker, as well as metabolic measures that include the metabolic syndrome and its components in European adults. This hypothesis was tested according to data from 1352 participants from the Observation of Cardiovascular Risk Factors in Luxembourg study, a nationwide, cross-sectional survey based in Luxembourg. Statistical methods consisted of descriptive and multivariable logistic regression analyses. The DII ranged from a minimum of −4.02 (most anti-inflammatory) to a maximum of 4.00 points, with a mean value of −0.41. Participants with higher DII score were significantly younger and had lower body mass index, waist circumferences, and systolic blood pressure levels. Other cardiovascular biomarkers including diastolic blood pressure, CRP, lipids, and glycemic biomarkers did not vary significantly across DII tertiles. Participants with proinflammatory (>1) DII scores had increased adjusted odds (odds ratio, 1.46; 95% confidence interval, 1.00-2.13) of having a low high-density lipoprotein cholesterol, compared with those with anti-inflammatory scores (DII ≤1). There were no significant relationships between high-sensitivity CRP and the DII. This study, which tested the inflammatory capacity of the DII outside the United States, did not detect a significant independent relationship with cardiometabolic biomarkers, by using Food Frequency Questionnaire–collected data. These results are informative and representative of a relevant step in directing future research for nutrition and diet quality.
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影响因子：
4
作者：
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