The breast cancer and the environment research centers: transdisciplinary research on the role of the environment in breast cancer etiology.
The breast cancer and the environment research centers: transdisciplinary research on the role of the environment in breast cancer etiology.
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DOI：
10.1289/ehp.0800120
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发表时间：
2009-12
影响因子：
10.4
通讯作者：
Breast Cancer and the Environment Research Centers
中科院分区：
文献类型：
--
作者：
Hiatt RA;Haslam SZ;Osuch J;Breast Cancer and the Environment Research Centers
我们介绍并描述了乳腺癌和环境研究中心（BCERC），这是一个跨学科的研究网络，以阐明环境因素在青春期发育中的作用，作为乳腺癌病因学的窗口。我们描述了整合到BCERC网络中的四个国家中心的组织。研究者使用基于生命周期中生物、行为和社会组织的多个层面的共同概念框架。该方法将基础生物学研究与啮齿动物模型和组织培养系统联系起来，对青春期前女孩进行协调的多中心流行病学队列研究，并将乳腺癌倡导者的社区成员作为研究团队的主要成员整合起来，以组成网络。相关文献回顾，描述当前的知识跨层次的组织。BCERC中的个人研究问题和假设是由我们在遗传、代谢、细胞、个体和环境（物理和社会）层面上的知识差距所驱动的。随着队列数据收集、动物实验和分析的进行，结果将通过跨学科的方法进行综合。中心研究人员正在解决大量与青春期早期发病有关的具体研究问题，这是乳腺癌的一个确定的危险因素。BCERC旨在初级预防乳腺癌的研究成果将由乳腺癌倡导者向科学界和公众传播，他们从一开始就是研究过程的组成部分。
We introduce and describe the Breast Cancer and the Environment Research Centers (BCERC), a research network with a transdisciplinary approach to elucidating the role of environmental factors in pubertal development as a window on breast cancer etiology. We describe the organization of four national centers integrated into the BCERC network. Investigators use a common conceptual framework based on multiple levels of biologic, behavioral, and social organization across the life span. The approach connects basic biologic studies with rodent models and tissue culture systems, a coordinated multicenter epidemiologic cohort study of prepubertal girls, and the integration of community members of breast cancer advocates as key members of the research team to comprise the network. Relevant literature is reviewed that describes current knowledge across levels of organization. Individual research questions and hypotheses in BCERC are driven by gaps in our knowledge that are presented at genetic, metabolic, cellular, individual, and environmental (physical and social) levels. As data collection on the cohort, animal experiments, and analyses proceed, results will be synthesized through a transdisciplinary approach. Center investigators are addressing a large number of specific research questions related to early pubertal onset, which is an established risk factor for breast cancer. BCERC research findings aimed at the primary prevention of breast cancer will be disseminated to the scientific community and to the public by breast cancer advocates, who have been integral members of the research process from its inception.
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影响因子：
8.8
作者：
Clavel-Chapelon, F
通讯作者：
Clavel-Chapelon, F
影响因子：
--
作者：
ANBAZHAGAN, R;BARTEK, J;GUSTERSON, BA
通讯作者：
GUSTERSON, BA
影响因子：
168.9
作者：
Cohn, BA;Cirillo, PM;Siiteri, PK
通讯作者：
Siiteri, PK
影响因子：
4.3
作者：
Baker, VA;Hepburn, PA;Ashby, J
通讯作者：
Ashby, J
年轻女性的DDT和乳腺癌：有关暴露年龄的重要性的新数据。
影响因子：
10.4
作者：
Cohn BA;Wolff MS;Cirillo PM;Sholtz RI
通讯作者：
Sholtz RI