DDT and breast cancer in young women: new data on the significance of age at exposure.
DDT and breast cancer in young women: new data on the significance of age at exposure.
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年轻女性的DDT和乳腺癌：有关暴露年龄的重要性的新数据。
DOI：
10.1289/ehp.10260
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发表时间：
2007-10
影响因子：
10.4
通讯作者：
Sholtz RI
中科院分区：
文献类型：
--
作者：
Cohn BA;Wolff MS;Cirillo PM;Sholtz RI
以前关于滴滴涕和乳腺癌的研究评估了在生命后期乳腺可能不容易受到影响的情况下，在大多数滴滴涕被消除之后，以及在滴滴涕被禁止之后的接触情况。我们调查了年轻女性在滴滴涕使用高峰期接触滴滴涕是否能预测乳腺癌。我们进行了一项前瞻性、巢式病例对照研究，使用1959-1967年期间从年轻女性中获得的血液样本，诊断的中位时间为17年。受试者是儿童健康和发展研究（加州奥克兰）的成员，他们在分娩后1-3天提供血液样本（平均年龄26岁）。50岁以前发生乳腺癌129例。对照组（n = 129）与出生年份的病例相匹配。测定血清中DDT的活性成分p，p′-DDT、低浓度污染物o，p′-DDT和含量最高的p，p ′-DDT代谢物p，p ′-DDE。高水平的血清p，p′-DDT预示着1931年以后出生的女性患乳腺癌的风险增加了5倍。这些妇女在1945年滴滴涕开始广泛使用时不到14岁，在滴滴涕使用达到高峰时大多不到20岁。在14岁之前未接触p，p′-DDT的妇女显示，p，p′-DDT与乳腺癌之间没有关联（年龄差异p = 0.02）。在生命早期接触p，p′-DDT可能会增加患乳腺癌的风险。许多美国妇女在童年时期大量接触滴滴涕，但还不到50岁。在生命早期接触滴滴涕对公共健康的影响可能很大。
Previous studies of DDT and breast cancer assessed exposure later in life when the breast may not have been vulnerable, after most DDT had been eliminated, and after DDT had been banned. We investigated whether DDT exposure in young women during the period of peak DDT use predicts breast cancer. We conducted a prospective, nested case–control study with a median time to diagnosis of 17 years using blood samples obtained from young women during 1959–1967. Subjects were members of the Child Health and Development Studies, Oakland, California, who provided blood samples 1–3 days after giving birth (mean age, 26 years). Cases (n = 129) developed breast cancer before the age of 50 years. Controls (n = 129) were matched to cases on birth year. Serum was assayed for p,p′-DDT, the active ingredient of DDT; o,p′-DDT, a low concentration contaminant; and p,p′-DDE, the most abundant p,p′-DDT metabolite. High levels of serum p,p′-DDT predicted a statistically significant 5-fold increased risk of breast cancer among women who were born after 1931. These women were under 14 years of age in 1945, when DDT came into widespread use, and mostly under 20 years as DDT use peaked. Women who were not exposed to p,p′-DDT before 14 years of age showed no association between p,p′-DDT and breast cancer (p = 0.02 for difference by age). Exposure to p,p′-DDT early in life may increase breast cancer risk. Many U.S. women heavily exposed to DDT in childhood have not yet reached 50 years of age. The public health significance of DDT exposure in early life may be large.
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影响因子：
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作者：
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