Exploration Disrupts Choice-Predictive Signals and Alters Dynamics in Prefrontal Cortex.

Exploration Disrupts Choice-Predictive Signals and Alters Dynamics in Prefrontal Cortex.
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探索破坏了选择性的信号,并改变了前额叶皮层中的动态。

DOI:
10.1016/j.neuron.2017.12.007
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发表时间:
2018-01-17
期刊:
影响因子:
16.2
通讯作者:
Moore T
Moore T
中科院分区:
医学1区
文献类型:
--
作者:
Ebitz RB;Albarran E;Moore T

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在不确定的环境中,决策者必须平衡两个目标:他们必须“利用”有价值的选择,但也要“探索”,以发现有价值的替代方案。探索和利用必然会改变大脑对相同刺激的反应,但人们对这些状态以及它们之间的转换如何改变大脑将感官信息转化为行动的方式知之甚少。为了解决这个问题,我们记录了前额叶感觉运动区的神经活动,而猴子自然地在探索和利用奖励选项之间切换。我们发现,探索大大减少了空间选择性,选择预测活动在单个神经元和延迟选择预测的人口动态。同时,奖励学习在大脑和行为中增加。这些结果表明,探索是与突然中断前额叶感觉运动控制和快速,奖励依赖重组的控制动态。这可以通过试错法来促进发现。
In uncertain environments, decision-makers must balance two goals: they must “exploit” rewarding options, but also “explore” in order to discover rewarding alternatives. Exploring and exploiting necessarily change how the brain responds to identical stimuli, but little is known about how these states, and transitions between them, change how the brain transforms sensory information into action. To address this question, we recorded neural activity in a prefrontal sensorimotor area while monkeys naturally switched between exploring and exploiting rewarding options. We found that exploration profoundly reduced spatially selective, choice-predictive activity in single neurons and delayed choice-predictive population dynamics. At the same time, reward learning was increased in brain and behavior. These results indicate that exploration is related to sudden disruptions in prefrontal sensorimotor control and rapid, reward-dependent reorganization of control dynamics. This may facilitate discovery through trial-and-error.
早期视觉皮层中额叶信号的自下而上的门控。
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